Partner and Program Growth
Ended 2025 with 107 partners and 407 active programs (net increase of 44 programs). Added 84 programs in 2025 — >20% more than 2024. Over 98% of active programs have contracted future economics to OmniAb.
Large Contracted Milestone and Royalty Backlog
OmniAb reports >$3.0 billion in total contracted milestone payments across active antibody programs and an average portfolio royalty rate of ~3.4%.
Program Progression and Clinical Momentum
25 program advancement events in 2025: 16 programs advanced discovery→preclinical, 4 advanced preclinical→Phase I, and 1 reached registration; 32 active clinical or approved programs at year-end. Clinical-stage programs carry >$350 million in remaining contracted milestone payments. Notable partner updates include Immunovant IMVT-1402 (multiple registrational/POC readouts 2026–2027), Teva TEV-408 funding support (up to $500M via Royalty Pharma) and Merck KGaA advancing M9140 to Phase III (anticipated start H1 2026).
New Platform Launches — OmniUltra and xPloration
Launched OmniUltra (transgenic chicken platform expressing ultra-long CDRH3 on human framework) in Dec 2025 to expand into peptide and picobody opportunities and broaden addressable market (management cited outreach to well over ~130 new potential companies). Launched xPloration partner access program (high-throughput single B-cell screening) in May 2025; deployed 2 instruments by year-end and generated ~ $800k revenue in 2025 from xPloration.
Disciplined Cost Management
Operating expense improvements: Q4 operating expense decreased to $24.1M from $26.7M (Q4 2024). Full‑year 2025 operating expense fell to $87.6M from $100.9M (2024). R&D down to $47.8M (from $55.1M) and G&A down to $29.2M (from $30.7M). Implemented workforce reduction of 22 employees to realize savings going forward.
Clear 2026 Financial Guidance and Path to Cash-Flow Positivity
Guidance for 2026: revenue $25M–$30M (implying recovery from 2025), operating expense $80M–$85M, cash operating expense $50M–$55M, expected year-end cash $30M–$35M, and continued focus on transitioning toward more royalty-driven recurring revenue and trajectory to positive cash flow.
Year-End Liquidity
Ended 2025 with $54M in cash, cash equivalents and short-term investments, providing runway to execute on 2026 plan.