Record Full-Year Revenue and Strong EPS Growth
Full-year 2025 revenue of $65.2 billion, up 45% vs 2024; full-year EPS grew 86% to $24.21, reflecting strong top-line and bottom-line performance.
Robust Q4 Performance
Q4 revenue grew 43% year-over-year; Q4 non-GAAP EPS of $7.54 (inclusive of $0.52 acquired IPR&D charges); non-GAAP performance margin improved to 47.2%, up 4.2 percentage points vs Q4 2024.
Key Products Driving Major Growth
Key products contributed over $13 billion in Q4 and grew 91% vs Q4 2024. Zepbound revenue more than doubled vs Q4 2024 and held ~70% share of new branded obesity prescriptions; Mounjaro and Zepbound led US volume growth (incretin analog total prescriptions +33% vs Q4 2024).
Market Leadership and Uptake by Franchise
Mounjaro expanded to >55% of new US diabetes prescriptions; Kisanlo became US market leader in amyloid-targeting therapies with >50% share (Q4 revenue $109 million); Omvo global revenue +55% YoY; Jayperca +30% YoY; Verzenio +3% YoY driven by ex-US volume.
Pipeline and Clinical Successes
Positive clinical data in more than 25 Phase 3 trials; 36 active Phase 3 programs; major readouts including pirtobrutinib (FDA full approval with expanded indication; PFS risk reduction ~80% vs bendamustine+rituximab and ~76% vs ibrutinib in subgroup) and multiple promising oncology, neuroscience and immunology results.
Incretin & Next-Gen Obesity Innovation
Submitted orforglipron for obesity in the US and >40 countries; retreutide TRIUMPH-4 produced average 29% body weight loss at 68 weeks and a 76% reduction in WOMAC pain (many patients pain-free); orforglipron maintained weight after switching from semaglutide (avg diff 0.9 kg) and largely maintained weight after tirzepatide (avg diff 5 kg).
Manufacturing Scale-Up and Capacity
Exceeded goal to produce 1.8x the number of incretin doses in 2025 vs 2024; new manufacturing sites online (Wisconsin and North Carolina) with plans for additional US and Europe facilities; since 2020 committed >$55 billion to manufacturing build-out.
Capital Allocation and Shareholder Returns
Distributed $1.3 billion in dividends and $1.5 billion in share repurchases in 2025, while continuing substantial R&D and commercial investments.
Commercial & Access Milestones
1 million patients engaged with US direct-to-patient platform in 2025; agreement with US government for Medicare/Medicaid access to obesity medicines with a $50/month patient out-of-pocket target; guidance for 2026 revenue of $80–$83 billion (midpoint +25% vs 2025) and EPS guidance $33.50–$35.