Strong Full-Year Revenue and EPS Growth
2025 enterprise revenue grew over 7% year-over-year and adjusted EPS grew 13% for the full year; management noted adjusted EPS growth of ~13% and margins improved by over 50 basis points versus prior year.
Robust Q4 Financial Performance
Q4 2025 revenue was $3.5 billion, up 5.6% YoY (organic +3.8%); adjusted operating income was $488 million (13.9% of revenue) vs $423 million (12.7% prior year); Q4 adjusted EPS was $4.07, up 18% YoY.
Diagnostics Segment Strength
Diagnostics Q4 revenue $2.7 billion, up 5.5% YoY with organic growth of 4.1%; total volume increased 2.2%; price/mix rose 3.3%; Diagnostics adjusted operating income $419 million (15.4% margin), up 150 basis points YoY.
Biopharma / Central Labs Momentum
Central Labs revenue in BLS grew 11.1% in the quarter (7.7% constant currency); BLS segment book-to-bill was strong at 1.16 for the quarter and 1.09 trailing 12 months; backlog ended Q4 at $8.7 billion with ~$2.7 billion expected to convert in 12 months.
Cash Generation and Capital Allocation
Full-year free cash flow was $1.2 billion (up 10% YoY). In Q4 the company invested $258 million in acquisitions, repurchased $225 million of stock and paid $59 million of dividends; share repurchase authorization remaining ~ $800 million.
Strategic M&A and Asset Wins
Completed multiple acquisitions and asset deals in Q4 and subsequent period (Parkview select outreach agreement, Community Health Systems outreach assets, Incyte Diagnostics anatomic pathology assets, and Empire City Labs assets post-quarter), contributing to >$1 billion of revenue growth over the past three years from hospital/regional deals.
Product and Technology Innovation
Launched 130+ new tests in 2025 focused on oncology, women's health, neurology and autoimmune disease; esoteric testing grew double-digits and increased share from 37.5% (Q1 2023) to 41.5% (Q4 2025). Introduced FDA-cleared blood test for Alzheimer's, expanded MRD testing, expanded OnDemand to 200+ biomarkers, and advanced AI/automation (pathology, cytology, microbiology) and a Roche automated mass spectrometry agreement.
2026 Outlook Showing Continued Growth
2026 guidance: enterprise revenue growth 4.7%–6% (midpoint ~5.4%), adjusted EPS $17.65–$18.25 implying ~9% growth at midpoint, free cash flow guidance $1.24B–$1.36B, expected margin expansion across both segments, and LaunchPad savings targeted $100M–$125M annually.