Strong Royalty and Revenue Growth
Full-year royalty revenue grew 48% year-over-year to $161M; core revenue (ex-Pelthos gain) was $240M, up 43% YoY; GAAP revenue was $268M (vs $167M in 2024). Q4 total revenue was $59.7M, up 39% YoY, with Q4 royalty revenue of $50.5M, up 45% YoY.
Material Earnings Expansion
Full-year core adjusted diluted EPS increased 42% year-over-year to $8.13; adjusted EPS exceeded original 2025 guidance by more than 30%. Q4 adjusted net income was $42.7M or $2.02 per diluted share versus $1.27 in the prior year period.
Commercial Portfolio Driving Scale
FILSPARI, Ohtuvayre and CAPVAXIVE were major contributors: FILSPARI U.S. Q4 net sales $103M (108% YoY) and ~$322M full-year U.S.; recorded $32M royalties on ~$355M global FILSPARI sales in 2025. Ohtuvayre U.S. full-year net sales ~$506M and CAPVAXIVE full-year net sales $755M.
Large Deployable Capital Base
Ended 2025 with $734M in cash/cash equivalents/short-term investments and, including equity holdings in Pelthos and credit facility capacity, over $1B in deployable capital to fund BD and royalty financings.
High Conviction Long-term Outlook
Management projects a 23% CAGR in royalty receipts from 2025–2030, with visibility to more than $430M in core revenue by 2030 and adjusted EPS visibility to over $13.50 per share by 2030.
Palvella QTORIN Phase 3 Win — Major Clinical Catalyst
Palvella's QTORIN rapamycin Phase 3 for mLM showed a +2.13 point improvement on the primary endpoint, 95% of participants improved, 86% much/very much improved, no drug-related SAEs, 98% continued into extension; NDA planned H2 2026 with potential to address >30,000 diagnosed U.S. mLM patients.
Successful Portfolio and Deal Execution
Completed special situations transaction (Pelthos/Channel merger & financing), rescued ZELSUVMI through bankruptcy to approval and out-licensed it (one-time fee recognized), and executed strategic re-licensing (lasofoxifene to LeonaBio with $90M PIPE).
Reaffirmed 2026 Guidance with Continued Royalty Growth
2026 guidance reaffirmed: adjusted EPS $8–$9; royalty revenue $200–$225M (implying ~32% growth at midpoint compared to 2025 core royalty base); total revenue $245–$285M.