Record Company Revenue and Year-over-Year Growth
Total net revenue for 2025 was $1.24 billion, up 4% versus 2024; fourth quarter net revenue was $358 million, up 20% year-over-year.
SUBLOCADE Strong Performance
SUBLOCADE net revenue reached a record $856 million in 2025, a 13% increase versus 2024; Q4 SUBLOCADE net revenue was $252 million, up 30% year-over-year. Full-year SUBLOCADE dispense volume grew 7% in 2025, with Q4 dispense growth of 12% year-over-year and 6% sequentially. Company expects mid-teens SUBLOCADE dispense unit growth in 2026 and SUBLOCADE net revenue guidance of $905–945 million (≈ +8% at midpoint).
Commercial Momentum — Prescribers, New Patients, and DTC Impact
New patient starts in Q4 were up 25% year-over-year; total active SUBLOCADE prescribers and prescribers treating 5+ patients each grew ~14% year-over-year and ~6% sequentially. The 'Move Forward in Recovery' DTC campaign drove a 60% increase in branded online search volume in Q4 versus pre-launch, a 70% increase in usage of the Find a SUBLOCADE Treatment Provider tool, and CRM enrollments rose to ~1,400/month in Q4 from ~60/month prior to the campaign.
Adjusted EBITDA and Margin Improvement
Adjusted EBITDA was a record $428 million for 2025, up 20% year-over-year with a 500 basis point margin improvement. Q4 adjusted EBITDA rose 91% year-over-year to $142 million. 2026 guidance targets adjusted EBITDA of $535–575 million (≈ +30% at midpoint) and a target adjusted EBITDA margin of ~48%.
Cost Discipline and Operating Expense Targets
Non-GAAP operating expenses were $622 million for 2025 (down 5% year-over-year) and $164 million in Q4 (down 8% year-over-year). Company expects non-GAAP operating expenses of $430–450 million in 2026 and stated operating expenses will not exceed $450 million in 2026.
Strengthened Financial Profile and Capital Deployment
Paid the outstanding $295 million DOJ obligation in 2025, eliminating a legacy liability. Ended 2025 with gross cash and investments of $222 million and net leverage below 1x. Company expects ~ $300 million in cash flow from operations in 2026 and announced a new $400 million share repurchase authorization (up to 18 months) while prioritizing debt management and opportunistic M&A.
Pipeline Readiness and Clear BD Criteria
Two phase II trials completed at end of 2025 with database lock expected by end of Q1 2026 and top-line results in Q2. Company defined business development criteria: commercial-stage assets, peak sales potential >$200M, long runway (mid-to-late 2030s), and differentiated products.