Strong Top-Line Growth
Total revenue of $1.27B in Q1 2026, up 21% year-over-year; net sales $1.10B, up 20% YoY. Reaffirmed full-year 2026 net sales guidance of $4.77B–$4.94B (up ~10%–13% vs prior year).
Core Business Ex-Jakafi Accelerating
Core business excluding Jakafi grew 63% YoY. Opzelura sales $143M (up 20% YoY; U.S. $106M up 12%; International $37M up 56%). Hematology & oncology net sales grew 116% to $204M; notable contributors: Niktimvo $55M, Monjuvi $49M (up 67% YoY), Zynyz $41M.
Pipeline and Regulatory Momentum
Multiple regulatory and development milestones: FDA accepted NDA for povorcitinib in moderate–severe HS; positive Phase III vitiligo results supporting future submission; Jakafi XR on track for potential mid‑year approval/launch; Monjuvi first-line DLBCL submissions expected H1 with approval/launch anticipated early 2027; Phase III initiation for mutant CALR antibody 989 (ET) on track midyear; KRAS G12D program (734) Phase III initiated in first-line PDAC.
Compelling Late‑Stage Clinical Data for Povorcitinib
HS 54‑week data: HiSCR50 up to 71%, HiSCR75 up to 57%, HiSCR100 up to 29%; up to 20% achieved complete clearance of draining tunnels/nodules. Vitiligo Phase III: F‑VASI ≥75% primary endpoint met in two trials (n≈456 on 30 mg dose); T‑VASI50 improvements achieved. Safety profile over 52 weeks consistent with prior studies; TEAEs of special interest 2%–3%, no new safety signals reported.
Commercial and Management Readiness
Senior leadership appointments to support growth: new CFO Suky Upadhyay; Pablo Cagnoni named President & Global Head R&D; Steven Stein as CMO and Head of Late‑stage Development; Mohamed Issa as EVP Head of U.S. Commercial. U.S. commercial operations consolidated to create launch-ready organization (targeting multiple launches in 2026–2027).
Improving Operating Leverage and Stable Cost of Sales
GAAP R&D $516M (up 18% YoY) and GAAP SG&A $328M (up 1% YoY). Ongoing operating expenses increased 14% YoY vs ongoing revenues up 19% YoY, indicating improving operating leverage. Cost of sales expected to remain ~9% of net sales.