Strong Top-Line Growth
Total revenues of $1.51B in Q4 2025 (up 28% YoY) and $5.14B for full-year 2025 (up 21% YoY). Product/net sales of $1.22B in Q4 (up 20% YoY) and $4.35B for the full year (up 20% YoY).
Core Business Expansion (ex-Jakafi)
Core business (excluding Jakafi) delivered approximately $1.26B in sales, representing a ~53% increase versus 2024, driven primarily by Opsilora, Nictimbo, and Manjovi.
Jakafi Performance and Visibility
Jakafi sales: Q4 $828M (up 7% YoY) and full-year $3.093B (up 11% YoY). Prescriptions increased 11% in Q4 and 9% for the full year. 2026 net sales guidance for Jakafi of $3.22B–$3.27B with prescriptions expected to grow high single digits.
Opsilora Momentum
Opsilora net sales Q4 $207M (up 28% YoY) and FY $678M (up 33% YoY). U.S. AD prescriptions +24% and vitiligo +15%. Pediatric AD launch already annualizing ~ $30M. International Opsilora/vitiligo sales doubled to $130M in 2025. 2026 sales guide $750M–$790M (~15% growth at midpoint).
Hematology & Oncology Surge
Hematology/oncology product sales Q4 $187M (up 121% YoY) and FY $583M (up 83% YoY). Nictimbo first-year sales ~$152M (13,000 infusions across >1,400 patients). Manjovi sales +20% driven by follicular lymphoma launch; Phase III frontline DLBCL results showed a 25% PFS improvement vs R‑CHOP.
Robust Pipeline Advancement and Regulatory Activity
Multiple late-stage moves: 14 pivotal trials across 7 assets expected underway by end of 2026; regulatory submissions filed (Jakafi XR, Opsilora, povastatinib MA in EU); tafasitamab approved in Europe and Japan and positive FRONT MIND phase III data shared.
Notable Oncology & Targeted Therapy Data
KRAS G12D inhibitor (seven34) showed 37% ORR and 78% disease control rate at planned phase 3 dose in predominantly late-line PDAC; phase 3 in first-line PDAC planned to start Q1 2026. Initiated phase 3 for TGFβ2 x PD‑1 bispecific in MSS colorectal cancer.
2026 Guidance and Financial Discipline
Full-year 2026 revenue guidance set at $4.77B–$4.94B (up 10%–13% YoY). Core ex-Jakafi sales guidance $1.57B–$1.69B (≈30% growth at midpoint). Expected FY GAAP R&D + SG&A operating expenses $3.495B–$3.675B; R&D expected ~+10% to advance late-stage programs while SG&A remains roughly flat.