Strong Full-Year Financial Performance
Sales up 7% to more than GBP 32 billion; core operating profit up 11%; core EPS up 12%; operating margin improved by 110 basis points (reported margin 29.9% impacted by currency).
Robust Cash Generation and Capital Returns
Cash generated from operations GBP 8.9 billion (more than GBP 10 billion excluding Zantac); free cash flow GBP 4.0 billion (more than GBP 5.0 billion excluding Zantac); underlying free cash generation > GBP 8 billion before investments; shareholder distributions ~GBP 4 billion (dividend upgraded 2p to 66p declared; 2026 dividend guidance 70p, +6%); 93 million shares repurchased (avg price 1473) with remaining GBP 0.6 billion buyback to complete; net debt/EBITDA ~1.3x stable.
Specialty Medicines Driving Growth
Specialty medicines sales increased 17%; Respiratory Immunology & Inflammation +18% (Benlysta +22%; Nucala +15% and delivered $2 billion, marking 10th consecutive year of double-digit growth); Oncology: Jemperli +89%, Ojjaara +60%; BLENREP approved in 15 markets; Exdensur approved in U.S., U.K. and Japan. Company expects specialty sales to grow low double-digit in 2026.
HIV Franchise Momentum
HIV sales up 11% in FY2025 (U.S. +14%); Cabenuva grew 42% and now represents >75% U.S. uptake in the quarter; long-acting injectables accounted for >75% of growth and ~1/3 of U.S. sales; Aplitude (long-acting PrEP) grew 62%; guidance for HIV mid- to high-single-digit growth in 2026 and Q6M regimen selection planned mid-year with Phase II progression toward a 2028–2030 launch cadence.
Productive R&D and Pipeline Progress
Five FDA approvals in 2025 and seven new pivotal trial starts; several important programs advancing (Efimosfermin Phase III starts, Nebula planned, Bepirovirsen positive Phase III B‑WELL 1 & 2 readouts for chronic hepatitis B, KALM-2 last patient first visit for Camlipixant with mid-2026 Phase III data expected, DREAM trials and other pivotal starts planned); company plans ~10 pivotal starts in 2026 including >5 ADC pivotal starts and further oncology, MASH and HIV pivotal programs.
Active Business Development to Enhance Pipeline
Acquisition agreement to acquire Rapp Therapeutics (Ozureprubart, an anti-IgE for food allergy in Phase II); added 3 potentially best-in-class clinical-stage specialty assets via BD; continued focus on smart BD to accelerate portfolio value.