Record Quarterly and Annual Revenue
Q4 2025 consolidated net sales of $143.1M (record) — up 36% reported / 34% constant currency vs. year-ago quarter. Full-year 2025 consolidated net sales of $507.4M (record) — up 32% vs. 2024.
Reaffirmed 2026 Guidance with Strong Growth Expectation
Company reaffirmed FY2026 net sales guidance of $600M–$620M, which implies >20% year-over-year growth at the midpoint and ~+$100M growth versus 2025 at the midpoint.
iDose TR Momentum and U.S. Glaucoma Growth
U.S. glaucoma Q4 net sales $86.4M — up 53% YoY, driven by iDose TR, which generated ~ $45M in Q4 and approximately $136M in 2025. Management expects U.S. glaucoma growth embedded in guidance to be ~30% YoY in 2026 driven entirely by iDose TR.
Epioxa FDA Approval and Commercial Launch Progress
FDA approval of Epioxa (topical corneal cross-linking without epithelial removal) announced in Q4; initial commercial launch activities underway with drug availability expected later in the current quarter. Positioned as first FDA‑approved topical, incision-free therapy for keratoconus.
Early Epioxa Market Access and Site Network Progress
Epioxa site-of-care network early deployment: O2n systems already deployed in locations covering nearly 50% of the U.S. population with a pipeline of systems expected to expand reach closer to 90%. Initial payer outreach engaged payers representing ~50% of commercially covered lives, including 4 of the top 5 commercial payers.
Encouraging Early Coverage and Coding Path
Several early positive coverage determinations reported (commercial and Medicaid). Permanent J-code submitted and expected effective July 2026; interim availability under a new technology miscellaneous J-code until then.
International and Corneal Franchise Growth
International glaucoma Q4 net sales $32.8M — up 18% reported / 13% constant currency YoY. Corneal health Q4 net sales $24.0M — up 12% YoY (Photrexa $21.4M). Management expects corneal health to grow modestly YoY in 2026 with volatility during the Photrexa→Epioxa transition.
Robust R&D and Clinical Pipeline Progress
Continued investment in R&D (> $1B invested since inception). Milestones: iStent infinite PMA enrollment completed; PRESERFLO 510(k) pivotal advancing; iDose TREX Phase IIb/III enrollment underway (Phase IIa showed IOP reductions of 8.6–10.8 mmHg through 3 months); iDose TRIO Phase IIIb commenced; iLink KC screening tool planned this year; ILution Phase II started; retinal GLK-401 FIH enrollment completed.
Capital Discipline with Operating-Leverage Target
CFO guidance to balance investments and revenues with goal of cash-flow breakeven/positive in 2026. OpEx expected to grow in the mid-teens YoY (management noted operating-leverage expectations despite increased spend for launches).