Cash Runway And Funding RiskHigh cash burn and a limited cash runway create funding and dilution risk for ongoing development and commercialization, which could pressure shares if additional financing is needed.
Market Perception And Measurement RiskMarket focus on absolute mean score metrics and concerns about perceived delivery complexity may lead investors and analysts to undervalue the therapy's durable and programmable response profile.
Retreatment And Real-world EffectivenessA sizable portion of patients did not achieve a meaningful response after a single administration, implying many will require retreatment and complicating commercial adoption and care pathways.