Full-Year Revenue and Guidance
Full-year 2025 revenue of $28.5M (down 7% YoY from $30.8M) with 2026 revenue guidance of $30M–$33M representing growth of ~5%–16% over 2025; Q1 2026 guidance of $6.5M–$6.7M (flat to +3%).
Non-GAAP Gross Margin Expansion
Non-GAAP gross margin improved to 47% for full-year 2025, up from 35% in 2024 — a 1,200 basis point improvement year over year; Q4 non-GAAP gross margin was 43% (vs. 42% a year ago).
Operating Expense and Cost Structure Transformation
Full-year 2025 non-GAAP operating expense was $36.6M, down 47% from $68.9M in 2024; Q4 non-GAAP operating expense was $9.7M, down 9% YoY. Since Q2 2023 the company removed approximately $100M of annualized non-GAAP operating expense and reduced headcount by over 300 people.
Consumables and Software Mix Shift Toward Higher-Quality Revenue
Consumables + software revenue grew to $20.4M for full-year 2025 (up 7% YoY from $19.0M) and increased as a share of total revenue from 62% to 71%, reflecting a strategic shift toward more predictable, higher-margin consumables and software revenue.
Installed Systems and Installations Outperformed Guidance
Installed 32 OGM systems in 2025, exceeding original guidance of 15–20 systems for the year; total installed base as of 12/31/2025 was 387 systems across 321 customers.
High-Value 'Routine-Use' Customer Base Driving Consumables
Approximately 130 routine-use customers (~40% of customers, ~45% of systems) drove ~83% of OGM consumables revenue. Average revenue per routine-use customer was ~$89K (about 2x the global average); 60 validated routine sites averaged ~$131K in consumables revenue.
Scientific Momentum and Publications Growth
Record year for OGM publications in 2025: 136 new peer-reviewed publications (up 25% YoY) and ~450 total publications (up from 359 in 2024). Clinical research genomes added ~1,190 in 2025, cumulative nearly 12,700 (CAGR ~30% since 2021).
Reimbursement Milestones Achieved
Established a second Category I CPT code for OGM (constitutional disorders) with a payment determination of $1,263.53; hematologic malignancy CPT payment increased 47% to $1,853.22 in 2026 CLFS — materially improving reimbursement infrastructure.
Product and Throughput Improvements
Commercial release of VIA 7.2 (extends automated workflows into constitutional disorders), Solve 3.8.3 (expanded control DB), and Stratus compute upgrade (advanced GPUs doubling weekly cancer sample throughput without hardware changes). IONIQ expansion supports high-purity DNA/RNA isolation at scale.
Operational Scale Evidence via Community and Partnerships
Bionano Symposium 2026 had >1,250 registrants from 73 countries; presentations highlighted scalable deployments (e.g., Radboud ramping to 3,000 samples/year, Labcorp showing Stratus can process up to 10,000 cancer samples/year) and cost/throughput advantages vs long-read sequencing.
Balance Sheet and Debt Milestone
Ended 2025 with $29.6M in cash, cash equivalents, and available-for-sale securities (including $10.3M restricted). Company expects cash runway into 2027 and senior secured convertible debt to be fully retired in May 2026, simplifying the balance sheet.