Amicus Acquisition Closed
Acquisition of Amicus completed, adding Galafold (Fabry) and Pombility / Opfolda (Pompe). Management expects the deal to accelerate growth and expand the commercial portfolio; incorporated Amicus P&L starting last week with plans to provide a detailed integration roadmap and peak revenue views on the Q2 call.
Upgraded 2026 Revenue Guidance (Pro Forma with Amicus)
Total 2026 revenue guidance raised to $3.825B–$3.925B, implying approximately 20% year-over-year growth at the midpoint after adding Amicus products.
Enzyme Therapies Guidance Increased ~30% at Midpoint
Enzyme Therapies revenue guidance raised to $2.725B–$2.775B (inclusive of Galafold and Pombility/Opfolda), representing roughly 30% year-over-year growth at the midpoint.
Strong Q1 Patient Demand and Voxzogo Patient Base Expansion
Total Q1 revenues were $766M. Voxzogo patient count increased by more than 20% year over year, with over half of new U.S. patient starts in Q1 from children under two and a roughly 10% decrease in average age at treatment initiation in that subgroup.
Enzyme Therapies Organic Growth in Q1
Enzyme Therapies revenue increased 6% year over year in Q1, led by Vimizim, Naglazyme, and Brineura; Palynziq showing expanding patient base after adolescent label expansion.
Non-GAAP EPS Guidance and Expected Accretion Timeline
Updated 2026 non-GAAP diluted EPS guidance of $4.85–$5.05. Management expects the Amicus acquisition to be slightly dilutive in 2026, accretive within the first 12 months after close, and substantially accretive beginning in 2027.
Robust Voxzogo Clinical and Long-Term Evidence
Voxzogo safety/efficacy database now exceeds 10,000 patient‑years with long‑term extension data showing durable height and arm span gains out to six–eight years; full approval sNDA submitted to FDA in April.
Multiple Near-Term Pipeline Catalysts
Several pivotal readouts expected in Q2 2026 including Voxzogo for hypochondroplasia (phase 3) and BMN‑401 (ENERGY‑3). BMN‑333 phase 2/3 enrollment underway and BMN‑351 early Duchenne data show dose‑dependent dystrophin increases and functional preservation signals.