Anticipated FDA Approval of Agios Pharma's Pyrukynd Expected to Boost Stock ValueValuation and Risks. Our Buy rating and $48 price target are based on a discounted cash flow analysis (DCF). In our DCF, we extend our estimates to 2038 and assign a 10% discount rate and -25% terminal growth rate. We are currently modeling mitapivat with 100% POS in PKD, 90% POS in thalassemia, and 50% POS in SCD, and have not included other pipeline assets or indications in our valuation.