Strong Top-Line Growth
Total revenue of $70.9M, up 45% year over year, driven primarily by MRD which accounted for ~95% of revenue.
MRD Revenue and Guidance Raise
MRD revenue grew 53% YoY to $67.1M. Full-year MRD revenue guidance raised to $260M–$270M (previously $255M–$265M); midpoint implies ~25% YoY growth (33% excluding milestones).
Clinical Volume and clonoSEQ Adoption
clonoSEQ clinical volumes up 41% YoY; Q1 tests ~32,600 (up 9% sequentially). Clinical business revenue up 54% YoY. Ordering clinicians grew 43% YoY to nearly 5,000.
Community and Blood-Based Testing Momentum
Community volumes grew 67% YoY and now represent 35% of total testing. Blood-based testing reached 49% of MRD volume; in multiple myeloma blood-based share rose to 29% (up 8 percentage points YoY).
Pricing and Reimbursement Gains
U.S. ASP increased 11% YoY to $1,360 per test. clonoSEQ added to Texas Medicaid policy manual (one of two tests listed) with up to six tests/year, and 10 commercial payer agreements signed in Q1.
Margin Expansion and Sequencing Efficiency
Sequencing gross margin improved 8 percentage points YoY to 70%, driven by NovaSeq X efficiencies, scale, and favorable pricing; company targeting >70% and a long-term north star ~75%.
Improved Segment Profitability and Backlog
MRD adjusted EBITDA of $12.1M versus a loss of $4.1M prior year. Pharma bookings/backlog ~ $254M, up 24% YoY, and ~190 active studies (111 primary/secondary; 23 primary).
Cash Position and Discipline
Ended quarter with approximately $222M in cash and operating plan to keep cash burn in the $15M–$20M range for 2026 while targeting positive adjusted EBITDA and free cash flow for the full company in 2026.
Immune Medicine Data and Partnerships
Proprietary immune dataset exceeding 6 million functional TCR–antigen pairs across ~50,000 antigens and 50+ HLA types; digital AI model outperformed public benchmarks. New RA target-discovery partnership with Pfizer (1,000+ patient samples).
Operational Execution: EMR Integrations & Repeat Utilization
Six new Epic accounts added YTD; seven of top-10 accounts fully integrated. Flatiron-enabled serial monitoring delivering strong pull-through with 72% of repeat orders due being fulfilled.