ZYNLONTA Commercial Brand Profitability
ZYNLONTA reached commercial brand profitability, maintaining its position in the competitive third-line-plus DLBCL space with sales of $69.3 million, consistent with the previous year.
Advancements in Clinical Trials
Completion of enrollment in pivotal Phase 3 LOTIS-5 trial and initial efficacy and safety update on Phase 1b LOTIS-7 trial. Initial data showed promising response rates.
Reduction in Operating Expenses
Achieved a double-digit reduction in operating expenses for the second consecutive year, with a 13% year-over-year decrease on a non-GAAP basis.
Strengthened Financial Position
Strengthened balance sheet through equity financing, providing a cash runway into the second half of 2026, with $251 million in cash and equivalents.
Promising Data Presentation
Promising Phase 2 data presented for indolent lymphomas at ASH, with strong response rates in high-risk relapsed/refractory FL and MZL patients.
Potential Revenue Growth
Potential peak revenue of $600 million to $1 billion in the US for ZYNLONTA, assuming regulatory approval and compendia listing.