Advancement of Tamibarotene as a New Standard of Care
Syros Pharmaceuticals is nearing a pivotal data readout from the SELECT-MDS-1 Phase III trial for tamibarotene, targeting higher-risk MDS patients with RARA gene overexpression. This milestone could transform the company's trajectory.
Significant Market Opportunity
The market opportunity for tamibarotene in the U.S. for patients with RARA overexpression is projected to be over $800 million by 2029, with the total market for higher-risk MDS therapeutics reaching approximately $1.6 billion.
Successful Completion of Futility Analysis
The SELECT-MDS-1 trial passed a prespecified futility analysis based on the primary endpoint, instilling confidence in the potential success of the trial.
Reduction in Net Loss
The net loss for the third quarter of 2024 was $6.4 million, a significant improvement from a net loss of $40.1 million in the third quarter of 2023.