Broad, Potent Preclinical Efficacy Of SIL204Demonstrated >90% inhibition across multiple KRAS mutations and tumor types indicates a platform-level therapeutic effect. This breadth strengthens the company’s competitive position in pan-KRAS RNAi, increasing the odds of multiple clinical opportunities and strategic partnerships over the next 2–6 months and beyond.
Completion Of Toxicology With No Systemic Organ ToxicityClear two‑species toxicology with no systemic organ toxicity materially reduces preclinical safety risk ahead of human dosing. That durable de‑risking supports on-time regulatory filings, trial starts, and more credible partner discussions, improving execution probability for clinical milestones.
Regulatory Progress Toward Phase 2/3 TrialSubmission of a Phase 2/3 application plus positive regulator feedback provides structural clarity on trial design and pathway to pivotal data. Regulatory alignment increases probability of timely trial initiation and eventual data that could enable licensing, partnerships, or larger funding rounds.