Clinical DevelopmentSilexion plans to initiate a Phase 2/3 study for SIL-204, with meetings scheduled with regulators to discuss and finalize the study design, indicating progress towards clinical development.
Efficacy DataSIL-204 demonstrated 97% tumor growth inhibition in a previously untested KRAS mutated line and successfully showed inhibition in both pancreatic and colorectal cancer lines.
Market PotentialKRAS mutations, which SIL-204 effectively targets, occur in high percentages of pancreatic, colorectal, non-small cell lung, and gastrointestinal cancers, indicating a broad market potential.