Clinical Strategy And Market ExpansionPlans to pursue both intratumoral and systemic administration and to include overall survival as the primary endpoint broaden the addressable patient population and could enhance the therapy's commercial appeal.
Preclinical EfficacyPreclinical evidence of pan-KRAS inhibition and anti-tumor activity across multiple KRAS mutations and cancer types strengthens confidence in SIL-204's mechanism and clinical potential.
Regulatory ProgressSubmission of a Phase 2/3 regulatory application in Israel and positive feedback from German regulators advances the clinical regulatory pathway for SIL-204 and supports multi-jurisdictional trial initiation.