Development Momentum And Market OpportunityProgression into planned Phase 2 programs in psoriasis and hidradenitis suppurativa, coupled with favorable readthrough from successful IL-17A/F drugs, points to a clear commercial pathway into a large validated market.
Dosing AdvantageExtended half-lives observed for ORKA-001 and ORKA-002 support potential for less frequent dosing than current therapies, which could improve patient adherence and competitive differentiation.
Safety ProfilePhase 1 findings showed no serious or severe treatment-emergent adverse events and no cases of oral candidiasis, suggesting a favorable safety profile that may ease regulatory scrutiny and physician acceptance.