Clinical RisksTesting higher exposures in psoriasis is de-risked by extensive clinical experience with high-dose IL-23p19 regimens in IBD.
CompetitionORKA-002 is positioned to become a strong competitor to currently marketed agents, indicating its potential for significant future growth but also the challenges of competing in a crowded market.
Regulatory ChallengesORKA announced FDA clearance to initiate the Phase 2a EVERLAST-A trial in moderate-to-severe plaque psoriasis earlier than expected, which can pose unforeseen challenges.