We believe the futility hurdle in r/r anal cancer is ORR of >20%. Prior clinical trials evaluating CPIs in anal cancer have shown ORR of 10-14% [S.Rao, J.-P.Spano, et al. ESMO Open. 2022, Vol. 7(4); A. Marabelle, J.-P. Delord, et al. Lancet, 2022, Vol. 7(5); S. Lonardi, F. Pietrantonio, et al. J Immunother Cancer. 2021, Vol. 9(11)].