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Lyra Therapeutics (LYRA)
NASDAQ:LYRA
US Market

Lyra Therapeutics (LYRA) AI Stock Analysis

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Lyra Therapeutics

(NASDAQ:LYRA)

42Neutral
Lyra Therapeutics is currently facing significant financial difficulties, characterized by negative revenue growth, increasing leverage, and negative cash flows. Technical indicators reflect a bearish trend, and the company's valuation is weak due to its unprofitability. These combined factors result in a low overall stock score, highlighting the need for strategic changes to improve its financial and market standing.
Positive Factors
Financial Performance
LYRA reported EPS of $(0.18) versus consensus of $(0.22), showing better than expected financial performance.
Regulatory Progress
The company received written responses from the FDA supporting a Type C meeting for LYR-210 development in CRSwNP patients.
Safety Data
Results from the ENLIGHTEN 1 52-week extension study continue to support the safety of LYR-210.
Negative Factors
Clinical Trial Risks
ENLIGHTEN I missed its primary endpoint, indicating increased risk for the ENLIGHTEN II readout.
Regulatory Uncertainty
There is a current lack of clarity around an approval path for LYR-210 and uncertainty around the outcome of the ENLIGHTEN II trial.
Stock Market Compliance
The company announced plans to implement a reverse stock split to maintain compliance with NASDAQ listing standards.

Lyra Therapeutics (LYRA) vs. S&P 500 (SPY)

Lyra Therapeutics Business Overview & Revenue Model

Company DescriptionLyra Therapeutics, Inc. (LYRA) is a clinical-stage therapeutics company focused on the development of innovative products for the treatment of ear, nose, and throat (ENT) diseases. The company leverages its proprietary XTreo platform to design and develop drug-eluting implants that deliver medication directly to the affected tissue over an extended period. Lyra's primary focus is on developing solutions for chronic rhinosinusitis, a prevalent condition that lacks optimal treatment options.
How the Company Makes MoneyLyra Therapeutics makes money through the development and commercialization of its proprietary drug-eluting implant products. The company's revenue model primarily hinges on bringing its therapeutic solutions to market, targeting partnerships with pharmaceutical companies for distribution and co-development. Lyra seeks to generate revenue through product sales, licensing agreements, and potential collaborations with other entities in the healthcare and pharmaceutical sectors. Additionally, Lyra may engage in strategic partnerships or joint ventures to expand its market reach and expedite the commercialization of its therapies. Revenue generation is largely dependent on successful clinical trials, regulatory approvals, and market adoption of its products.

Lyra Therapeutics Financial Statement Overview

Summary
Lyra Therapeutics is facing financial challenges, with consistent losses and negative cash flows. The biotechnology industry often requires substantial investment, but the company's high leverage and shrinking equity base pose risks. While there are strengths in operational cash efficiency, overall financial health is concerning, necessitating strategic adjustments to improve profitability and reduce reliance on external funding.
Income Statement
40
Negative
Lyra Therapeutics has experienced a decrease in total revenue from $1,558,000 in 2023 to $1,534,000 in 2024. The net profit margin remains negative, reflecting ongoing losses. Despite revenue growth in prior years, the company struggles with high operating losses, as evidenced by the negative EBIT and EBITDA margins.
Balance Sheet
45
Neutral
The company's debt-to-equity ratio has increased, indicating higher leverage, but remains manageable. Stockholders' equity has decreased significantly, suggesting potential financial instability. Despite a high equity ratio, the reduction in total assets and equity raises concerns about long-term sustainability.
Cash Flow
50
Neutral
Lyra has a negative free cash flow, indicating cash outflows exceeding inflows. Operating cash flow remains negative, though there is a high operating cash flow to net income ratio, reflecting cash efficiency in operations. However, the reliance on financing activities for cash inflows indicates a need for external funding.
Breakdown
TTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income StatementTotal Revenue
1.47M1.53M1.56M1.36M285.00K0.00
Gross Profit
-12.01M1.53M1.56M296.00K-716.00K-95.00K
EBIT
-101.42M-96.35M-67.12M-56.31M-43.62M-22.21M
EBITDA
-67.04M-96.35M-65.25M-53.92M-42.61M-22.11M
Net Income Common Stockholders
-97.61M-93.44M-62.68M-55.28M-42.41M-22.05M
Balance SheetCash, Cash Equivalents and Short-Term Investments
23.89M40.58M102.75M97.89M45.75M74.59M
Total Assets
0.0066.35M142.60M109.97M54.87M80.83M
Total Debt
0.0034.38M26.88M2.22M1.45M2.44M
Net Debt
23.89M-6.20M4.53M-30.33M-44.29M-72.15M
Total Liabilities
0.0054.75M53.18M29.21M20.55M6.34M
Stockholders Equity
23.28M11.59M89.42M80.75M34.32M74.49M
Cash FlowFree Cash Flow
-80.90M-72.35M-64.35M-43.55M-29.20M-22.92M
Operating Cash Flow
-77.72M-70.01M-63.30M-43.38M-25.82M-21.14M
Investing Cash Flow
49.81M80.31M-12.58M-65.01M-3.38M-1.77M
Financing Cash Flow
27.45M8.53M65.69M96.26M359.00K87.70M

Lyra Therapeutics Technical Analysis

Technical Analysis Sentiment
Negative
Last Price0.12
Price Trends
50DMA
0.18
Negative
100DMA
0.19
Negative
200DMA
0.24
Negative
Market Momentum
MACD
-0.01
Positive
RSI
22.56
Positive
STOCH
5.87
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For LYRA, the sentiment is Negative. The current price of 0.12 is below the 20-day moving average (MA) of 0.17, below the 50-day MA of 0.18, and below the 200-day MA of 0.24, indicating a bearish trend. The MACD of -0.01 indicates Positive momentum. The RSI at 22.56 is Positive, neither overbought nor oversold. The STOCH value of 5.87 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for LYRA.

Lyra Therapeutics Risk Analysis

Lyra Therapeutics disclosed 87 risk factors in its most recent earnings report. Lyra Therapeutics reported the most risks in the “Tech & Innovation” category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Lyra Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (48)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
64
Neutral
$124.50B-3.15%11.64%-114.72%
55
Neutral
$35.12B-414.62%22.97%38.54%
49
Neutral
$4.80B-93.03%-10.48%-18.79%
48
Neutral
$6.86B1.11-50.22%2.47%16.71%1.53%
46
Neutral
$2.92B-19.20%-89.95%-123.71%
42
Neutral
$7.91M-184.99%-1.54%-7.20%
42
Neutral
$30.29M60.38%5.59%83.59%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
LYRA
Lyra Therapeutics
0.12
-5.16
-97.73%
ALNY
Alnylam Pharma
266.83
115.35
76.15%
IONS
Ionis Pharmaceuticals
28.71
-14.12
-32.97%
VRTX
Vertex Pharmaceuticals
483.49
79.48
19.67%
FGEN
FibroGen
0.31
-1.27
-80.38%
CRSP
Crispr Therapeutics AG
34.19
-30.87
-47.45%

Lyra Therapeutics Corporate Events

Product-Related AnnouncementsBusiness Operations and Strategy
Lyra Therapeutics Pursues ENLIGHTEN 2 Trial for LYR-210
Neutral
Jan 10, 2025

Lyra Therapeutics has announced a corporate presentation detailing their ongoing ENLIGHTEN 2 Phase 3 trial for LYR-210, targeting the treatment of CRS. Despite previous setbacks, including the failure of the ENLIGHTEN 1 trial to meet its primary endpoint, the company is continuing its efforts with updated trials and anticipates results in the second quarter of 2025. The announcement highlights Lyra’s challenges such as funding needs and market acceptance, but also emphasizes the potential of LYR-210 in aligning with ENT practices and addressing unmet needs in CRS treatments.

Glossary
OutperformA stock rated as "Outperform" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests that the stock is likely to deliver higher returns compared to the average returns of other stocks in the same sector or market index. Investors might consider this stock a good buying opportunity.
NeutralA stock rated as "Neutral" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly attractive nor unattractive for investment. Investors may consider holding onto the stock, as it is not expected to either significantly outperform or underperform the market.
UnderperformA stock rated as "Underperform" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests that the stock may deliver lower returns compared to the average returns of other stocks in the same sector or market index. Investors might consider selling the stock or avoiding it as an investment.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.