Clinical And Development RisksRisks include delays in advancing pipeline candidates into and through clinical assessment, failure to generate favorable clinical data from ongoing programs, particularly KRRO-110 in AATD, and possible long-term dilution risk.
Operational RisksManagement announced a restructuring program, aiming to extend the runway into 2027, thereby allowing for clinical readouts/derisking of the two lead programs.
Safety ConcernsSafety remains an important consideration for investors given concerns over potential LNP-mediated safety events, which are believed to be overblown.