Clinical And Regulatory Execution RiskKey execution risks persist around first-in-human trial design, durability of dosing in humans, and the potential for regulators to demand demonstration of reduced clinical events rather than only ammonia lowering.
Financial And Investor Confidence RiskFailure of the earlier KRRO-110 program triggered a significant share selloff and weakened investor trust, while limited cash runway increases the likelihood of future financing and potential dilution.
Operational And Collaboration DisruptionA substantial workforce reduction, a paused collaboration with Novo, and the chief medical officer's resignation signal operational disruption that could delay development timelines and heighten execution risk.