Clinical SetbacksKorro announced KRRO-110 did not reach target levels of functional AAT following a single administration in AATD patients.
Strategic ChallengesKorro is abandoning the current KRRO-110 formulation and pivoting to a GalNAc-conjugated AATD construct, with a new candidate not expected until 1H26—placing the program clearly behind competitors.
Workforce And Financial ChangesAlongside the scientific setback, Korro announced a 34% workforce reduction and extended its cash runway to 2H27 as it reprioritizes resources toward KRRO-121 for hyperammonemia.