Clinical Trial EfficacyInterim Phase 2 results indicate the ENV-105 plus Erleada combination produced durable responses in an early cohort, with a majority of evaluable patients remaining progression-free and several showing objective declines, suggesting meaningful efficacy that could extend time on anti-androgen therapy.
Mechanism Of Action And Re-sensitizationTargeting CD105 with ENV-105 has shown preclinical and early clinical signals of re-sensitizing tumors to standard therapies, offering a potential route to overcome resistance and expand treatment options.
Safety ProfilePhase 2 safety data reported no dose-limiting toxicities or unexpected adverse effects for ENV-105, indicating a tolerable profile that could support wider use in combination regimens.