Candidiasis And Safety MonitoringReported rates of esophageal candidiasis in short-term studies raise safety concerns that may necessitate additional monitoring, patient counseling, or mitigation strategies before broad adoption.
Limited Physician FamiliarityOnly a minority of surveyed gastroenterologists reported strong familiarity with EP-104GI and recent clinical data, which could slow clinical uptake and commercial momentum.
Small Trial Cohorts And Statistical UncertaintyAnalyst warns that small cohort sizes in early RESOLVE data create uncertainty and that randomized, larger trials are required to confirm the observed efficacy and durability.