Endpoint RobustnessReduced extracellular volume measurements from imaging quality problems materially weakened statistical power for the primary endpoint and may undermine confidence in the trial's conclusions.
Imaging Data QualityImaging limitations reduced the number of analyzable patients in ARCHER, creating gaps in the dataset that complicate interpretation of trial findings.
Statistical PowerA smaller analyzable sample due to imaging issues likely left the primary endpoint underpowered, increasing uncertainty about the formal significance of observed improvements.