Group Sales Growth
Group sales grew 7% in 2025 (constant exchange rates). Pharma sales grew 9% to CHF 47.7 billion; Diagnostics reported +2% overall but +7% excluding China healthcare pricing reforms.
Strong Operating Performance
Core operating profit increased 13% year‑over‑year, delivering a core operating margin expansion of +1.9 percentage points. Pharma core operating profit margin reached ~49.2%.
Core EPS and IFRS Net Income Progress
Core EPS rose ~11% for the year; IFRS net income increased 58% (noting a large prior‑year impairment base; adjusted operational comparison ~+20%).
Pipeline and Regulatory Momentum
Substantial Q4/Q4‑to‑date pipeline progress with multiple regulatory approvals and filings: EU approval for Gazyva in lupus nephritis; U.S. and EU approval of Lunsumio subcutaneous for third‑line+ follicular lymphoma; U.S. filing for giredestrant in post‑CDKi ER+/HER2‑ metastatic breast cancer.
Multiple Positive Phase III/II Readouts
Numerous successful trials including two positive Phase III fenebrutinib studies (FENtrepid in PPMS and FENhance in RMS), positive lidERA (giredestrant) adjuvant result with IDFS hazard ratio 0.70, positive Enspryng and vamikibart data, PiaSky aHUS result, additional positive Phase IIIs for Gazyva (INS and SLE) and a positive Phase II for CT‑388 in obesity.
Record Advancement of NMEs
A record 10 new molecular entities (NMEs) moved into Phase III — the largest cohort in Roche history, improving the risk‑adjusted pipeline value and future revenue potential.
Diagnostics Innovation & New Product Launches
Regulatory approvals and launches in Diagnostics included the Elecsys dengue antigen test, cobas BV/CV assay and automated clinical mass spectrometry (cobas Mass Spec 601). AXELIOS Sequencing Solution launched, positioned as a high‑throughput NGS offering (potential >CHF 1bn opportunities per product).
On‑market Brand Strength
Strong growth from key brands: Phesgo (+48%), Vabysmo (global growth; U.S. uptake improving), Xolair (+32%, >100,000 food allergy patients treated since launch), Ocrevus (9% growth and accelerating subcutaneous uptake), Polivy (U.S. patient share 36% in 1L DLBCL), Evrysdi (>21,000 patients on treatment). Hematology grew ~15% (CHF 8.6bn).
Financial Discipline and Capital Allocation
Company met/upgraded guidance during the year (ended at the top end of guidance), continued dividend increases in CHF, reduced net debt by CHF 1.1 billion year‑end, and committed to invest USD 50 billion in the U.S. over 5 years (R&D and PP&E).
Clear 2026 Guidance
Management guided 2026 to mid‑single‑digit group sales growth and high single‑digit core EPS growth, while expecting continued dividend increases and margin stabilization/expansion.