Full-Year Sales and Margin Achievement
Full-year 2025 sales grew 8% (high single-digit). Core operating income rose 14% and Novartis achieved a 40.1% core margin (target reached two years early). Core operating income reached approximately $21.9 billion.
Record Free Cash Flow and EPS Growth
Free cash flow reached an all-time high of $17.6 billion (up 8% year-over-year). Core EPS increased 17% to $8.98.
Strong Performance from Priority Brands
Multiple priority brands delivered high growth: Kisqali up 57% (FY) to $4.8B with 44% Q4 growth (54% excluding U.S. RD adjustments, U.S. 62%); Kesimpta up 36% to $4.4B; Scemblix reached blockbuster status with 87% Q4 growth and 41% NBRx share; Pluvicto grew 42% constant currency to $2B (U.S. pre-taxane sales +75%); Leqvio grew 57% FY (46% Q4) and reached blockbuster status; Cosentyx grew 8% to $6.7B.
Pluvicto and RLT Scale-up
Pluvicto showed dynamic uptake (PSMAfore launch) with PSMA share of 16% in the setting and over 790 treatment sites in the U.S.; new manufacturing sites coming online (California, Florida, Japan, China) to expand capacity for radioligand therapy launches.
Successful New Product Launches and Early Commercial Momentum
Rhapsido U.S. launch showed encouraging early results with >2,000 HCP starts in sampling/bridge program and strong demand from allergists/dermatologists; Itvisma (gene therapy) approved in U.S. with broad label and multi-blockbuster potential estimated >$3B.
Pipeline Progress and Pivotal Readouts
Met the majority of 2025 R&D milestones and positioned for seven pivotal readouts in 2026 (pelacarsen, remibrutinib, ianalumab, DUX4 interim, others), demonstrating active pipeline execution and replacement power for future growth.
Pelabresib MANIFEST Results and Regulatory Path
Pelabresib Phase III 96-week MANIFEST data showed deep, durable spleen responses, sustained symptom and anemia improvements, comparable safety to ruxolitinib and fewer deaths/progressions; agreement with EU to file in 2026 and plan for new Phase III in U.S./China/Japan.
Capital Allocation and Shareholder Returns
Completed $15B buyback in early July and launched a new up-to-$10B program (≈$7.7B remaining). Proposed dividend CHF 3.70 per share (6% increase in CHF, double-digit in USD), continuing long track record of dividend growth. R&D investment >$10B (+8% YOY).
Long-Term Growth Confidence
Company reaffirmed 5%–6% sales CAGR for 2025–2030 and expects to return to 40%+ core margin by 2029, signaling confidence in mid-term trajectory despite near-term headwinds.