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Brainstorm Cell Therapeutics (BCLI)
OTHER OTC:BCLI

Brainstorm Cell Therapeutics (BCLI) AI Stock Analysis

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BCLI

Brainstorm Cell Therapeutics

(OTC:BCLI)

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Neutral 44 (OpenAI - 5.2)
Rating:44Neutral
Price Target:
$0.58
▲(0.34% Upside)
Overall score is held down mainly by weak financial performance (large operating losses, ongoing cash burn, and equity/funding risk). Technicals are also soft with the stock below key longer-term averages. Corporate events add some support via new financing and development progress, but carry dilution/financing risk, and valuation remains constrained by negative earnings and no dividend.
Positive Factors
Regulatory Advancements
Securing a special protocol assessment with the FDA reduces regulatory risks, enhancing the potential for successful approval and commercialization of NurOwn.
Strategic Partnerships
Collaborations with IQVIA and Pluri Inc. strengthen trial execution and production capabilities, supporting efficient development and potential market entry of NurOwn.
Cost Reduction Achievements
Significant cost reductions in R&D and administrative expenses improve financial efficiency, aiding long-term sustainability and resource allocation for strategic initiatives.
Negative Factors
Financial Constraints
Ongoing net losses and reduced cash reserves highlight financial challenges, potentially limiting operational flexibility and investment in growth initiatives.
Delays in Phase 3b Trial
Delays in the Phase 3b trial initiation could postpone potential market entry and revenue generation, impacting long-term growth prospects.
Skepticism About Efficacy
Skepticism about NurOwn's efficacy requires robust clinical data to gain market and investor confidence, crucial for successful commercialization.

Brainstorm Cell Therapeutics (BCLI) vs. SPDR S&P 500 ETF (SPY)

Brainstorm Cell Therapeutics Business Overview & Revenue Model

Company DescriptionBrainstorm Cell Therapeutics Inc., a biotechnology company, engages in the development and commercialization of autologous cellular therapies for the treatment of neurodegenerative diseases. The company, through its NurOwn proprietary cell therapy platform, leverages cell culture methods to induce autologous bone marrow-derived mesenchymal stem cells to secrete high levels of neurotrophic factors, modulate neuroinflammatory and neurodegenerative disease processes, promote neuronal survival, and enhance neurological function. It is developing NurOwn, which has completed Phase III clinical trial for the treatment of amyotrophic lateral sclerosis; and Phase II clinical trial for the treatment of progressive multiple sclerosis and alzheimer's disease, as well as for other neurodegenerative diseases. The company has a partnership with Catalent for manufacturing NurOwn. The company was formerly known as Golden Hand Resources Inc. and changed its name to Brainstorm Cell Therapeutics Inc. in November 2004. Brainstorm Cell Therapeutics Inc. was incorporated in 2000 and is headquartered in New York, New York.
How the Company Makes MoneyBrainstorm Cell Therapeutics generates revenue through the development and commercialization of its proprietary cellular therapies. The company's primary revenue stream is expected to come from the sale or licensing of NurOwn, pending regulatory approval and successful commercialization. Additionally, Brainstorm may engage in strategic partnerships and collaborations with pharmaceutical companies, research institutions, and other stakeholders to advance its clinical programs and expand its market reach. These partnerships may provide upfront payments, milestone payments, and royalties, contributing to the company's earnings. Other potential revenue sources include government grants and funding from non-profit organizations that support research in neurodegenerative diseases.

Brainstorm Cell Therapeutics Earnings Call Summary

Earnings Call Date:Aug 14, 2025
(Q2-2025)
|
% Change Since: |
Next Earnings Date:Apr 01, 2026
Earnings Call Sentiment Neutral
The earnings call highlighted significant advancements towards clinical trials and strong community support, but these were overshadowed by financial challenges, NASDAQ delisting, and funding uncertainties. The sentiment is balanced between optimism for future trials and concern over current financial hurdles.
Q2-2025 Updates
Positive Updates
FDA Clearance for Phase IIIb Trial
Brainstorm Cell Therapeutics received FDA clearance to initiate a pivotal Phase IIIb trial, ENDURANCE, for NurOwn in early-stage ALS patients. This provides regulatory clarity and strengthens the trial's foundation.
Manufacturing Partnership with Minaris
Secured a partnership with Minaris Advanced Therapies to enhance U.S.-based manufacturing capabilities for the upcoming clinical trial.
Support from ALS Community
A citizens petition was filed with the FDA by ALS patients and families, requesting a de novo review of NurOwn's data, showcasing strong community support.
Negative Updates
NASDAQ Delisting
Brainstorm's stock transitioned from NASDAQ to OTCQB due to noncompliance with NASDAQ's minimum shareholder equity requirement.
Increased Net Loss
Reported a net loss of $2.9 million for Q2 2025, compared to $2.5 million in Q2 2024, indicating financial challenges.
Funding Challenges for Clinical Trials
Inability to secure funding for the Phase IIIb trial and meet NASDAQ requirements due to regulatory uncertainties created by the citizens petition.
Company Guidance
During the Brainstorm Cell Therapeutics Second Quarter 2025 Conference Call, the company emphasized its commitment to advancing the NurOwn platform for ALS treatment through a planned Phase IIIb trial called ENDURANCE, following FDA clearance in May. The trial's design has been agreed upon with the FDA under a Special Protocol Assessment (SPA), aiming to support a future Biologics License Application (BLA). Financially, Brainstorm reported R&D expenditures of $1.1 million for the quarter ending June 30, 2025, up from $0.9 million in 2024, and a net loss of $2.9 million compared to $2.5 million the previous year. The company is actively seeking funding to initiate the trial and regain NASDAQ compliance, following a transition to the OTCQB. Additionally, a Citizens Petition has been filed with the FDA by ALS patients and families, advocating for a de novo review of NurOwn's data, which includes promising five-year survival statistics from an expanded access program.

Brainstorm Cell Therapeutics Financial Statement Overview

Summary
Brainstorm Cell Therapeutics faces significant financial challenges, with ongoing losses and negative cash flows. Despite a slight improvement in equity, the company's financial stability is still at risk, requiring strategic changes to improve revenue and cash flow.
Income Statement
Brainstorm Cell Therapeutics shows a significant net loss for multiple years with minimal revenue in 2024. The gross profit margin is 100% due to its small revenue covering costs, but net profit margins remain negative. The revenue growth rate is not meaningful due to zero revenue in previous years. Continued negative EBIT and EBITDA margins indicate ongoing operational challenges.
Balance Sheet
The company has a fluctuating equity position, currently positive but previously negative. The debt-to-equity ratio is relatively low at 0.87, indicating some financial stability. However, the equity ratio is modest due to past negative equity, reflecting potential risk.
Cash Flow
Operating cash flow remains negative, indicating insufficient cash generation from operations. Free cash flow is also negative, with a significant growth in free cash flow loss compared to past years. The operating cash flow to net income ratio is not meaningful due to consistent net losses.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue849.00K849.00K0.000.000.000.00
Gross Profit581.00K849.00K-265.00K-285.00K-260.00K-219.00K
EBITDA-10.69M-11.31M-16.93M-23.99M-24.28M-31.46M
Net Income-10.85M11.62M-17.19M-24.28M-24.46M-31.81M
Balance Sheet
Total Assets872.00K1.83M4.21M8.45M29.28M51.26M
Cash, Cash Equivalents and Short-Term Investments5.00K187.00K1.30M2.98M22.09M41.94M
Total Debt326.00K720.00K1.27M4.09M5.08M7.22M
Total Liabilities50.00K9.60M9.07M11.47M9.94M15.79M
Stockholders Equity822.00K-7.76M-4.86M-3.02M19.34M35.46M
Cash Flow
Free Cash Flow-7.28M-9.09M-20.48M-19.35M-26.59M-35.57M
Operating Cash Flow-7.28M-9.09M-20.46M-19.32M-26.27M-35.19M
Investing Cash Flow12.00K12.00K2.19M998.00K323.00K-4.45M
Financing Cash Flow7.16M7.97M18.98M238.00K6.97M76.94M

Brainstorm Cell Therapeutics Technical Analysis

Technical Analysis Sentiment
Positive
Last Price0.58
Price Trends
50DMA
0.61
Negative
100DMA
0.65
Negative
200DMA
0.84
Negative
Market Momentum
MACD
-0.01
Negative
RSI
49.24
Neutral
STOCH
24.46
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For BCLI, the sentiment is Positive. The current price of 0.58 is above the 20-day moving average (MA) of 0.58, below the 50-day MA of 0.61, and below the 200-day MA of 0.84, indicating a neutral trend. The MACD of -0.01 indicates Negative momentum. The RSI at 49.24 is Neutral, neither overbought nor oversold. The STOCH value of 24.46 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for BCLI.

Brainstorm Cell Therapeutics Risk Analysis

Brainstorm Cell Therapeutics disclosed 64 risk factors in its most recent earnings report. Brainstorm Cell Therapeutics reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Brainstorm Cell Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
47
Neutral
$6.48M-2.25-24.80%1371.65%64.13%
45
Neutral
$7.03M-1.23-145.65%68.59%
44
Neutral
$5.96M-0.4058.09%
40
Underperform
$3.79M-0.06-41.05%57.35%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
BCLI
Brainstorm Cell Therapeutics
0.58
-1.46
-71.57%
AIM
AIM ImmunoTech
1.25
-17.92
-93.48%
TCRT
Alaunos Therapeutics
2.85
1.04
57.46%
PMCB
PharmaCyte Biotech
0.90
-0.63
-41.31%
CYCN
Cyclerion Therapeutics
1.71
-1.21
-41.44%

Brainstorm Cell Therapeutics Corporate Events

Private Placements and Financing
Brainstorm Cell Therapeutics Secures New Convertible Debt Financing
Neutral
Jan 9, 2026

On December 31, 2025, and January 5 and 6, 2026, Brainstorm Cell Therapeutics Inc. entered into three unsecured securities purchase transactions with institutional investors, issuing promissory and convertible promissory notes with original issue discounts and one-time interest charges, in aggregate principal amounts of $94,300, $94,875 and $140,000, respectively. The financings, which were conducted as private placements exempt from SEC registration, provided the company with short- to medium-term funding through discounted debt that may convert into equity at variable prices upon events of default or after specified holding periods, introducing potential future equity dilution while strengthening near-term liquidity and embedding investor protections such as default premiums, ownership caps, cross-defaults, and repayment rights tied to future financings.

The most recent analyst rating on (BCLI) stock is a Hold with a $0.58 price target. To see the full list of analyst forecasts on Brainstorm Cell Therapeutics stock, see the BCLI Stock Forecast page.

Financial DisclosuresPrivate Placements and Financing
BrainStorm Cell Therapeutics Enters Securities Purchase Agreement
Positive
Nov 14, 2025

On November 10, 2025, BrainStorm Cell Therapeutics entered into a securities purchase agreement with Labrys Fund II, L.P., issuing a promissory note of $143,750 and receiving $121,500 after fees. The note is convertible into shares upon default, with specific payment terms leading to maturity on November 10, 2026. Additionally, BrainStorm announced its third-quarter financial results for 2025, highlighting a decrease in net loss compared to the previous year, and provided updates on its NurOwn Phase 3b clinical trial for ALS, which has received FDA clearance. The trial aims to enroll 200 participants and is designed to support a Biologics License Application. A Citizen Petition was filed with the FDA by the ALS community, underscoring interest in NurOwn’s potential.

The most recent analyst rating on (BCLI) stock is a Hold with a $6.60 price target. To see the full list of analyst forecasts on Brainstorm Cell Therapeutics stock, see the BCLI Stock Forecast page.

Business Operations and StrategyPrivate Placements and Financing
Brainstorm Cell Therapeutics Secures New Financing Agreement
Positive
Nov 6, 2025

On October 31, 2025, Brainstorm Cell Therapeutics entered into a securities purchase agreement with Vanquish Funding Group, issuing a promissory note for $182,400 and receiving $155,000 after fees. This agreement allows for potential additional financing of up to $2 million over the next year, impacting the company’s financial strategy and providing opportunities for further development.

The most recent analyst rating on (BCLI) stock is a Hold with a $6.60 price target. To see the full list of analyst forecasts on Brainstorm Cell Therapeutics stock, see the BCLI Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Dec 30, 2025