Successful TECELRA Launch
The TECELRA launch has shown fantastic momentum with 20 authorized treatment centers representing two-thirds of the planned network, ahead of schedule. In Q1 2025, they've apheresed 10 patients with expectations to invoice 3 to 4 times as many patients as in the prior quarter.
Promising Reimbursement Success
Over 70% of commercial and Medicare lives are in plans with policies to cover TECELRA, with zero reimbursement denials to date, showcasing strong support from payers.
Manufacturing Efficiency
TECELRA manufacturing has been highly efficient with a 100% success rate in product release and no manufacturing failures. The turnaround time is less than the target of 30 days.
Lete-cel Progress
Lete-cel, the next product in the sarcoma franchise, is on track for BLA submission later this year. The IGNYTE-ESO trial showed a 42% overall response rate, with six complete responses among 64 patients.
Cost-Saving Measures
The company has announced a pause on spending for preclinical programs targeting PRAME and CD70, reducing forward cash flow demands by $75 million to $100 million, in addition to $300 million saved from previous restructuring.