Strong Full-Year and Q4 Sales Growth
Net sales for full year 2025 were EUR 43.6 billion, a 9.9% increase at constant exchange rates. Q4 2025 sales were EUR 11.3 billion, up 13.3% year-over-year.
Robust Launch Performance and New Product Sales
New launches reached EUR 5.7 billion in sales and grew 34% in 2025. ALTUVIIIO reached blockbuster status with EUR 1.2 billion in full-year sales; AYVAKIT achieved $725 million annual pro forma sales; Beyfortus totaled EUR 1.8 billion (up 9.5%).
Dupixent Momentum
Dupixent posted EUR 4.2 billion in Q4 and EUR 15.7 billion in annual sales, with patient numbers increasing more than 30% over the past year; growth drivers include expansion into COPD, CSU and BP and a new regulatory acceptance for AFRS.
Vaccines Leadership and Impact
Vaccines sales were EUR 7.9 billion for 2025. Beyfortus has protected over 11 million babies across 45+ countries with real-world effectiveness of 87%–98%, estimated to have prevented ~200,000 hospitalizations to date.
Improved Profitability and Margins
Business gross margin expanded by 1.8 percentage points to 77.5%. Business operating income increased 11.9% with a BOI margin of 27.8%. Business EPS grew strongly (Q4 business EPS growth noted at 26.7%); full-year business EPS excluding buyback grew 12.2% and grew 15% including the completed EUR 5 billion buyback.
Strong Free Cash Flow and Balance Sheet
Free cash flow was EUR 8.1 billion (18.5% of sales) in 2025; inventory was reduced by nearly 30 days. Net debt was EUR 11 billion with a conservative 0.8x net debt-to-EBITDA ratio and maintained AA rating, enabling M&A and shareholder returns including a proposed EUR 1 billion buyback in 2026 and a 5% dividend increase to EUR 4.12.
Pipeline Delivery and Regulatory Progress
In 2025 the company delivered 12 Phase III readouts, 15 Phase II readouts, added 10 molecules to Phase I (including 3 gene therapies), obtained 20 regulatory approvals and 22 acceptances (including 9 priority reviews), and launched three new medicines/vaccines (Qfitlia, Wayrilz, Nuvaxovid).
Strategic BD & M&A Deployment
Opella divestment proceeds (~EUR 10.4 billion) were deployed into value-creating BD/M&A including Blueprint, Vicebio, Dren Bio DR-0201, Vigil and the proposed Dynavax acquisition (adds HEPLISAV-B and a shingles candidate).
Operational & Sustainability Initiatives
Continued investments in manufacturing capacity (strategic focus on U.S.) and participation in development of PAS 2090, the first industry-wide global standard for measuring and reducing environmental impact of medicines and vaccines.
2026 Financial Guidance
Guidance for full-year 2026: high single-digit sales growth and business EPS growing slightly faster than sales (profitable growth expected to continue over at least five years).