Group Revenue and Profit Growth
Group sales grew 7% (FY2025). Pharma sales up 9% and Diagnostics up 2% (would be +7% ex-China). Core operating profit increased 13% with a core operating margin expansion of +1.9 percentage points; core EPS rose ~11%.
Strong Pharma Commercial Performance
Multiple on-market drivers: Phesgo global conversion >50% (now ~54%), Ocrevus passed CHF 7 billion annual sales and is targeted to reach CHF 9 billion by 2029 (including ~CHF 2 billion from subcut), Hematology +15% (CHF 8.6bn), Polivy US patient share ~36%, Xolair grew ~32% (reaching ~CHF 3bn), Evrysdi >21,000 patients on treatment, Vabysmo continued global growth (12% for year) with expected acceleration in 2026.
Exceptional Q4 and Pipeline Readouts
Busy positive Q4 pipeline: two positive Phase III fenebrutinib readouts (PPMS FENtrepid and RMS FENhance 2), positive giredestrant lidERA (adjuvant HR 0.70 for IDFS; OS trending HR 0.79), additional positive Phase III results for Gazyva (INS, SLE), positive Phase III for Enspryng in MOG-AD, PiaSky in aHUS, and positive Phase II CT-388 in obesity.
Record R&D Progress — Late-Stage Acceleration
A record 10 NMEs moved into Phase III (company statement); 19 potential launches planned by decade-end (not all assured). Management notes >60% of NMEs post-bar and 66% of late-stage projects have best-in-disease potential.
Regulatory and Launch Milestones
Regulatory wins and filings: EU approval for Gazyva in lupus nephritis; U.S. and EU approvals for subcutaneous Lunsumio; U.S. filing for giredestrant in post-CDKi metastatic ER+/HER2- breast cancer. Diagnostics approvals include Elecsys dengue test, cobas BV/CV and Mass Spec menu expansion.
Diagnostics Innovation and Commercial Opportunities
Launch of AXELIOS Sequencing Solution (next-generation sequencing) with management citing >CHF 1 billion sales potential, plus a first fully automated clinical mass spec (cobas Mass Spec 601) and new assays (dengue antigen, cobas BV/CV).
Cash Deployment and US Investment Agreement
Agreement with U.S. government provides tariff and demo exemptions in exchange for commitments (including Medicaid rebates) and a pledged US investment of USD 50 billion over five years (R&D and PP&E), supporting manufacturing and R&D expansion in U.S. sites.
Operational Discipline and Guidance Delivery
Company delivered on upgraded guidance: FY sales growth of 7% (mid-single-digit target) and core EPS upgraded and achieved in the double-digit band; 2026 guidance set to mid-single-digit sales growth and high single-digit core EPS growth with expectation to further increase dividend in CHF.