Strong Top-Line Growth
Total revenue of $26.6M in Q4 2025, up 24% year-over-year; full year 2025 revenue of $100M, up 25% versus 2024.
RNS System Momentum
RNS System revenue of $22.4M in Q4 2025, up 26% year-over-year; RNS grew 25% for the full year 2025. RNS growth in H2 2025 was 29%, with the majority of growth driven by Level 4 centers.
Improved Gross Margins
Company gross margin >77% (77.4% in Q4 2025 vs 75.4% in Q4 2024, roughly +200 bps year-over-year). RNS gross margin >80% (80.5% in Q4 2025; full year RNS gross margin 81.9%).
Positive Adjusted EBITDA and Cash Generation
Second consecutive quarter of positive adjusted EBITDA at $0.9M in Q4 2025 (improvement of $1.9M YoY). Positive operating cash flow of ≈$0.5M and free cash flow of ≈$0.4M in Q4. Cash, cash equivalents and short-term investments totaled $61.1M, up $1.1M from the prior quarter.
Regulatory and Clinical Milestone — IGE Submission Accepted
PMA supplement for idiopathic generalized epilepsy (IGE) submitted Dec 15 and accepted by FDA to initiate the 180-day review. NAUTILUS 18-month results show a 77% median seizure rate reduction with favorable safety in a highly refractory population.
Product and AI Pipeline Progress
Seizure ID (AI-enabled seizure detection) submitted and expected approval in H1 2026; clinician platform moving to cloud. Progress on remote programming, a NeuroPace foundation model leveraging >24M iEEG recordings and continued next-generation platform development.
Reiterated 2026 Revenue Guidance and Focused Commercial Investment
Reiterated full year 2026 revenue guidance of $98M–$100M (implying underlying RNS growth of 20%–22%). Planned investments include targeted sales headcount, incentive updates and expanded nurse navigator resources to improve funnel conversion and access.
Operating Leverage Demonstrated
Q4 operating expense growth of 13% versus revenue growth of 24%, and normalized full year operating expense growth of ~13% versus revenue growth of 25%, indicating improved leverage as the business scales.