The earnings call highlighted significant scientific advancements and strategic collaborations, demonstrating Nautilus' platform's potential and financial prudence. However, challenges in immediate revenue generation and the necessity of market development for the proteoform opportunity present ongoing hurdles.

Company Guidance -

Q3 2025

During the Nautilus Biotechnology Second Quarter 2025 Earnings Conference Call, the company highlighted several key metrics and developments. Nautilus reported total operating expenses of $17.1 million, an 18% decrease from $20.8 million in the same quarter of 2024, with research and development expenses at $10.4 million and general and administrative expenses at $6.7 million. The company's net loss was $15.0 million compared to $18.0 million in the prior year period. Nautilus ended the quarter with approximately $179.5 million in cash, cash equivalents, and investments, projecting this to extend their cash runway through 2027. The company emphasized their manuscript release demonstrating unprecedented dynamic range and reproducibility in proteoform analysis, with a median coefficient of variation (CV) of 1.5% within experiments and approximately 5% across multiple instruments. Nautilus also announced two new collaborations with major U.S. research institutes, aiming to demonstrate the platform's capabilities and performance.

Scientific Validation Milestone

Nautilus publicly shared the first preprint featuring novel data generated using its platform, demonstrating unprecedented dynamic range and industry-leading reproducibility in proteoform analysis, potentially opening new avenues for neurodegenerative disease diagnostics.

Strong Financial Management

Operating expenses for Q2 2025 were $17.1 million, an 18% decrease from $20.8 million in the same quarter of 2024, attributed to cost optimization and headcount reduction.

Strategic Collaborations

Nautilus signed two collaborations with major U.S. research institutes, laying the foundation for future revenue opportunities and demonstrating platform capabilities with customer samples.

Platform Reproducibility and Sensitivity

Nautilus' platform demonstrated a median CV of 1.5% within experiments and approximately 5% across multiple instruments, significantly outperforming traditional methods with 40% to 80% variation.

Nautilus Biotechnolgy (NAUT) Earnings, Revenues Date & History

The upcoming earnings date is based on a company’s previous reporting, and may be updated when the actual date is announced

Daily Earnings Calendar >

NAUT Earnings History

Report Date	Fiscal Quarter	Forecast / EPS	Last Year's EPS	EPS YoY Change	Slides	Play Transcript
Nov 04, 2025	2025 (Q3)	-0.15 / -	-0.13	―	―	―
Jul 31, 2025	2025 (Q2)	-0.15 / -0.12	-0.14	14.29% (+0.02)	―
Apr 29, 2025	2025 (Q1)	-0.15 / -0.13	-0.15	13.33% (+0.02)	―
Feb 27, 2025	2024 (Q4)	-0.15 / -0.14	-0.14	0.00% (0.00)
Oct 29, 2024	2024 (Q3)	-0.17 / -0.13	-0.13	0.00% (0.00)
Jul 30, 2024	2024 (Q2)	-0.16 / -0.14	-0.13	-7.69% (-0.01)	―
Apr 30, 2024	2024 (Q1)	-0.16 / -0.15	-0.12	-25.00% (-0.03)	―
Feb 28, 2024	2023 (Q4)	-0.16 / -0.14	-0.11	-27.27% (-0.03)
Oct 31, 2023	2023 (Q3)	-0.15 / -0.13	-0.11	-18.18% (-0.02)	―
Aug 02, 2023	2023 (Q2)	-0.15 / -0.13	-0.12	-8.33% (-0.01)	―

The table shows recent earnings report dates and whether the forecast was beat or missed. See the change in forecast and EPS from the previous year.

Beat

Missed

NAUT Earnings-Related Price Changes

Report Date	Price 1 Day Before	Price 1 Day After	Percentage Change
Jul 31, 2025	$0.76	$0.76	0.00%
Apr 29, 2025	$0.68	$0.73	+7.35%
Feb 27, 2025	$1.43	$1.17	-18.18%
Oct 29, 2024	$2.81	$2.77	-1.42%

Earnings announcements can affect a stock’s price. This table shows the stock's price the day before and the day after recent earnings reports, including the percentage change.

FAQ

When does Nautilus Biotechnolgy (NAUT) report earnings?

Nautilus Biotechnolgy (NAUT) is schdueled to report earning on Nov 04, 2025, Before Open (Confirmed).

What is Nautilus Biotechnolgy (NAUT) earnings time?

Nautilus Biotechnolgy (NAUT) earnings time is at Nov 04, 2025, Before Open (Confirmed).

Where can I see when companies are reporting earnings?

You can see which companies are reporting today on our designated earnings calendar.

What companies are reporting earnings today?

You can see a list of the companies which are reporting today on TipRanks earnings calendar.

What is NAUT EPS forecast?

NAUT EPS forecast for the fiscal quarter 2025 (Q3) is -0.15.

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