Voyager Instrument Debut and Positive Community Reception
Public unveiling of the Nautilus Voyager instrument at US HUPO with highly positive feedback from researchers; provided the proteomics community its first tangible view of the system and reinforced interest from prospective customers.
Early Access Program Launched Ahead of Schedule
Iterative Mapping Early Access Program launched in January earlier than planned, beginning with the Tau proteoform assay; enables partners to submit samples, receive data and provide feedback to inform workflows and future commercial readiness (early engagements not expected to drive near-term revenue).
External Collaborations and Biological Validation
Strong external validation from collaborations with Buck Institute and Allen Institute producing biologically compelling tau proteoform data (differences across brain regions and disease severity) presented at World HUPO and US HUPO; supports claim of unique biological insight unavailable from conventional proteomics.
New Grant-Funded Collaboration for Alpha-Synuclein
18-month collaboration with Weill Cornell Medicine-Qatar and The Michael J. Fox Foundation focused on alpha-synuclein proteoforms; $1.6M total funding with approximately $1.2M to Nautilus to be recognized as work progresses over 2026-2027, extending platform into Parkinson's disease applications.
Technical Progress on Assays and Platform
Progress on broadscale assay configuration change with initial data from new chips encouraging; largest-scale experiments yet demonstrated decoding of proteins from complex mixtures (including cell lysates); fabrication improvements and indications of increased on-target binding.
Tau Proteoform Assay Ready for Early Access
Verification and validation of Tau proteoform assay largely complete and meeting requirements for accuracy, dynamic range, reproducibility and stability; on schedule to begin processing Early Access Program samples by end of Q1 2026.
Operational Discipline and Reduced Spend
Fiscal 2025 cost reductions: Q4 operating expenses $15.4M (down 23% YoY vs prior year period), full-year operating expenses $66.8M (down 18% YoY). R&D expenses $41.1M (down $9.4M or 19% YoY) and G&A $25.7M (down $5.3M or 17% YoY).
Improved Cash Position and Lower Burn
Ending cash, cash equivalents and investments of $156.1M; cash burn in 2025 was $50.2M, down from $57.8M in 2024 (approximately a 13% reduction). Company expects cash runway to extend through 2027 under current plan.