Record-Breaking Revenue Growth
Mirum Pharmaceuticals reported total revenues of $111.6 million for Q1 2025, representing a 61% growth over the first quarter of the previous year.
Updated Revenue Guidance
The company increased its full-year revenue guidance to $435 million to $450 million, driven by robust growth across its commercial medicines.
Regulatory Approvals
Three important regulatory approvals were received, including FDA approval of CTEXLI for CTX treatment and LIVMARLI's approval in Japan for PFIC and Alagille syndrome.
Strong Performance of LIVMARLI
Total global net product sales for LIVMARLI grew to $73.2 million in Q1, an increase of over 70% compared to Q1 2024.
Pipeline Progress
The VISTAS study of Volixibat in PSC is nearing enrollment completion, with top-line data expected in Q2 2026. The VANTAGE study in PBC showed a 3.8 point reduction from baseline in pruritus.
Improved Financial Position
Operating cash flow was positive for the quarter, with a cash contribution margin improvement from approximately 47% to 53% year-over-year.