Strong CARVYKTI Sales Growth
CARVYKTI net trade sales of approximately $597 million in Q1 2026, representing 52% year-over-year growth (36% U.S. YoY; >200% ex-U.S. YoY) and 8% sequential growth vs Q4 2025.
Operational and Manufacturing Excellence
Manufacturing success rate of 99%, median turnaround time of ~29 days, and >95% on-time order releases, demonstrating reliable supply and support for broader adoption.
Earlier-Line Penetration Accelerating
Patients in second and third line represented 41% of CARVYKTI apheresis volume in the U.S. in Q1 2026, up from 29% a year ago, indicating meaningful shift toward earlier use and community adoption.
Global Commercial Footprint Expansion
CARVYKTI available across 18 global markets and >300 global treatment sites; 148 authorized U.S. treatment centers (about one-third community), supporting scale and access.
Improving Profitability Trajectory
Company expects company-wide adjusted profitability in 2026. Q1 adjusted net loss narrowed to $11 million ($0.03 per diluted share) vs adjusted net loss of $27 million ($0.07) in Q1 2025, reflecting substantial improvement.
Healthy Balance Sheet and Cash Position
Ended Q1 with approximately $835 million in cash, cash equivalents and time deposits and no long-term debt, providing flexibility to invest in pipeline and manufacturing.
Pipeline Progress and Near-Term Data
Multiple In Vivo and next-generation programs advancing: BCMA In Vivo (autoimmune) and GPRC5D In Vivo (multiple myeloma) in Phase I; LB2501 (CD19/CD20 In Vivo) in Phase I for NHL with potential first clinical data planned for a major meeting midyear; expectation to file 1–2 U.S. INDs in 2026.
Collaboration Revenue Supporting Scale
Collaboration revenue of approximately $298 million in Q1 (primarily related to CARVYKTI/J&J collaboration), contributing to total revenue of $305 million for the quarter.