Strong Revenue Growth
Total revenue increased 19% year-over-year to $3.7 billion in FY2025, reflecting growth across royalty streams and commercialized medicines.
Rapid Growth of Proprietary Medicines
Sales of Genmab's proprietary medicines totaled $632 million, up 54% year-over-year and accounting for ~28% of total revenue growth.
EPKINLY Commercial Momentum
EPKINLY generated $468 million in sales in 2025, a 67% year-over-year increase; approved in more than 65 countries and positioned as a dual-indication bispecific across DLBCL and follicular lymphoma.
TIVDAK Market Traction
TIVDAK sales reached $164 million in 2025, up 26% year-over-year, with approvals in the EU, U.K., Japan and continued U.S. growth as a standard of care in recurrent/metastatic cervical cancer.
Improved Profitability
Operating profit expanded to $1.26 billion in 2025 despite strategic investments, demonstrating operating leverage as the business scales.
Bolt-on Acquisition Strengthening Late‑Stage Pipeline
Merus acquisition added petosemtamab to Genmab's late-stage portfolio, expanding high-impact assets alongside EPKINLY and Rina-S and increasing potential future launch catalysts.
Compelling Early Clinical Data for Petosemtamab
In first-line head and neck cancer, petosemtamab plus pembrolizumab achieved a 63% response rate, versus ~19% with standard of care—supporting multibillion-dollar potential.
Robust Late‑Stage Pipeline and Regulatory Recognition
Three late-stage programs (EPKINLY, Rina-S, petosemtamab) hold five combined breakthrough therapy designations; company expects up to six potentially registrational data readouts in 2026 that could enable 2027 launches.
Guidance and Capital Allocation Discipline
2026 midpoint guidance anticipates ~14% revenue growth and $1.15 billion operating profit at midpoint while reaffirming capital allocation priorities, pipeline investment, and a target to reduce gross leverage below 3x by end of 2027.
Debt Financing Completed
Completed a $5.5 billion debt offering ($2.5B fixed, $3.0B floating) with ~$1.6B of the floating portion hedged to fixed (net ~$4.1B fixed) to support the Merus acquisition and integration.