Total Revenue Growth
Q1 2026 total revenue grew 25% year-over-year, reflecting diversified revenue from royalties (DARZALEX, Kesimpta) and increasing product sales from Genmab's proprietary medicines.
Proprietary Portfolio Sales Momentum
Proprietary product sales totaled $176 million in Q1 (up 43% year-over-year), driven by strong uptake of EPKINLY and Tivdak across new and established markets.
EPKINLY Commercial Performance and Label Update
EPKINLY sales reached $137 million in the quarter (up 52% year-over-year). Key commercial and regulatory wins include fixed-duration approval with R2 in second-line FL, approvals in >65 countries (many dual indications), and an FDA label revision removing a required 24-hour hospitalization recommendation for first full dose in third-line DLBCL—expected to broaden outpatient/community use.
Tivdak Growth and Geographic Expansion
Tivdak sales were $39 million in Q1 (up 18% year-over-year). Continued leadership in the U.S. recurrent/metastatic cervical cancer market and expansion efforts in Japan, Europe (direct commercialization in Japan and Europe), and the U.K. (private prescribing launch and NICE/SMC engagement) support further growth.
Profitability While Investing in Growth
Genmab grew operating profit by 23% in Q1 despite stepping up investments in late-stage development and launch readiness. 2026 guidance remains on track with a midpoint revenue growth expectation of ~14% and planned operating expenses of ~$2.7–2.9 billion.
Rina-S Development Acceleration and Milestones
Rina-S program advanced materially: RAINFOL-02 (Phase III in second-line plus platinum-resistant ovarian cancer) completed enrollment ahead of expectations, bringing pivotal Phase III data into 2026; two new Phase III trials (including a chemo-replacement in platinum-sensitive ovarian cancer and the first frontline endometrial trial) are anticipated to start in coming months. Two datasets for Rina-S in platinum-resistant ovarian cancer are expected in H2 2026, supporting potential 2027 launches.
Petosemtamab Progress & Merus Integration
Petosemtamab development remains on track with one or more readouts expected this year; Merus integration is underway and being pursued to capture the full value of petosemtamab, while acquisition-related expenses/amortization are excluded from the presented results (reconciliation in appendix).
Clinical Execution and Faster-than-Expected Enrollment
Several trials (including RAINFOL-02 and multiple EPKINLY trials) have accrued faster than originally projected, accelerating expected readouts and creating a catalyst-rich 2026 with potential supporting launches in 2027.