Clinical Trial FailuresThe final median overall survival (OS) data from the TRIFOUR study confirmed the program's failure in triple-negative breast cancer (TNBC), justifying our prior zero valuation contribution for this indication.
Efficacy ConcernsThe updated survival data from the Phase 1b/2 TRIFOUR study serve as the final confirmation of the program's lack of efficacy in TNBC.
Endpoint MissThe TRIFOUR Phase 2 study in TNBC did not meet its primary ORR endpoint, comparing nadunolimab in combination with chemotherapy vs. chemotherapy alone.