Strong Year-over-Year Sales Growth for LOQTORZI
LOQTORZI net sales increased 61% versus Q1 2025 with Q1 2026 net sales of $11.8M (down modestly QoQ from $12.4M in Q4 2025, a ~4.8% quarter-over-quarter decline attributed to seasonality and weather). Management forecasts ramp targets of ~$15M/quarter in 2026, $30–35M/quarter in 2027 and a peak market share of ~$44M/quarter (~$175M/year) by 2028.
Record New Patient Starts and Increased Account Penetration
Q1 saw all-time high new patient starts for LOQTORZI. Breadth and depth of ordering accounts increased 21% and treatment duration is increasing quarter-over-quarter, supporting management's multi-quarter demand growth outlook of 10%–15% average demand growth per quarter in 2026.
Pipeline Clinical Milestones: CATALYST-202 Fully Enrolled
Completed target accrual to the randomized CATALYST-202 (72-patient, 3-arm) first-line hepatocellular carcinoma study; initial data expected midyear. Prior casdozokitug triplet data showed ORR 38% and complete response 17% versus historical atezo/bev 30% ORR and 7.7% CR, supporting further development and biomarker analyses (including IL-27 and circulating tumor DNA).
Accelerating Tagmokitug Clinical Program
Multiple tagmokitug cohorts are actively accruing (40-patient HNSCC expansion, 40-patient upper GI adeno cohort, ESCC cohorts, MSS CRC cohort without liver mets); initial data for several cohorts anticipated midyear to H2 2026. The first nonproprietary combination with J&J pasritamig (prostate) is advancing, with first-patient expected in the fall.
Strong Pharmacology & Positioning for Tagmokitug
Company reports tagmokitug meets 'right drug' criteria: linear dose-dependent PK, target-binding potency, dose-dependent immune/pharmacodynamic effects, and an acceptable safety profile alone and combined with toripalimab — positioning it favorably amid mixed CCR8-class results from other developers.
Improved Cost Discipline and Strengthened Liquidity
Follow-on equity offering generated $54M of net proceeds (including full exercise of overallotment). Cash, cash equivalents and investments were $167M at quarter-end. Operating expense reductions: R&D from continuing operations of $21.5M (down from $24.4M, ~11.9% decrease YoY) and SG&A of $23.1M (down from $26.0M, ~11.2% decrease YoY), reflecting tighter spending discipline and exit from biosimilars.