Strategic Transformation and Balance Sheet Strengthening
Completed transition to an innovative oncology company, divested biosimilar franchise for $250 million, and reduced secured and convertible debt by over 90% from ~$480 million to $38.8 million at year-end 2025.
Strong LOQTORZI Commercial Momentum
LOQTORZI net revenue grew to $40.8 million for full-year 2025 versus $19.1 million in 2024, representing 113% year-over-year growth; Q4 net revenue was $12.4 million (11% growth over Q3) with quarter-over-quarter demand growth of 15.5%.
Compelling Long-Term Survival Data
Six-year overall survival data for LOQTORZI plus chemotherapy shows median ~65 months versus <36 months for chemo alone — approximately a 2.5-year (30+ month) survival advantage, supporting strong clinical differentiation and NCCN positioning.
Cash and Financing Position
Cash, cash equivalents and investments of $172.1 million at year-end 2025 plus a recent ~$50 million follow-on raise to support commercial expansion and pipeline investments.
Reduced Interest Expense and Improved Liquidity
Cash paid for interest fell to $9.9 million in 2025 versus $25.4 million in 2024, a savings of >$15 million following debt paydowns; earliest debt maturity extended to May 2029.
Operational Efficiency and Cost Discipline
Headcount reduced by ~35% (from ~228 to ~147) and Q4 SG&A from continuing operations decreased to $23.6 million from $29.6 million in Q4 2024 (down ~20%), reflecting ongoing cost control during transformation.
Promising Pipeline Data and Near-Term Readouts
Tagmokitug demonstrated selective depletion of CCR8+ tumor Tregs and a marked increase in CD8 T cells with an observed partial response in a 4th-line head & neck patient refractory to prior PD-1 therapy; casdozokitug (with Atezo/Bev) showed ORR 38% and CR 17% in first-line HCC (ASCO GI 2025). Multiple initial data readouts expected from mid-2026 onward.
Strategic Partnership Validation
Collaboration with Johnson & Johnson to study tagmokitug combined with pasritamig (a KLK2-targeting TCE) — validation of scientific approach and strategy to be Treg depleter of choice; potential to offset pivotal costs via ex-U.S. partnerships.