Successful Attruby Launch
Attruby generated $36.7 million in revenue in its first quarter, with 2,072 unique patients receiving a prescription and 756 unique healthcare providers writing at least one prescription. The product demonstrated a 42% relative risk reduction in cardiovascular hospitalization and mortality at 30 months, including a 50% reduction in cardiovascular hospitalization.
Pipeline Progress
BridgeBio's pipeline includes three Phase 3 readouts expected in the next year, with trials in limb-girdle muscular dystrophy 2I, achondroplasia, and ADH1 on track. Additionally, the hypochondroplasia trial enrolled its first patient quickly, and positive POC data for encaleret in hypoparathyroidism was announced.
Financial Performance
Total revenues for Q1 2025 were $116.6 million, exceeding expectations. The company's NPV increased by 9% due to various factors, including better-than-anticipated revenue from Attruby and a successful convertible offering.
Strong Market Positioning
Attruby is positioned as the most cost-effective therapy in the ATTR-CM market, being 10% less expensive than tafamidis and 50% less expensive than vutrisiran. It also offers a free trial program for all patients and lifetime free drug for trial participants.