Persistent Cash BurnConsistent negative operating and free cash flow forces reliance on external funding, increasing dilution and execution risk. Over a multi-quarter horizon this constrains clinical investment pacing and negotiating leverage with partners, making long-term program funding uncertain.
Declining Equity And Total AssetsMaterial declines in equity and assets reflect depletion of shareholder capital to fund operations. This reduces the balance sheet buffer against development setbacks, heightens the probability of further capital raises, and weakens financial resilience during lengthy clinical timelines.
Large Operating Losses & Negative MarginsSevere operating losses and deeply negative net margins (extreme in recent years) show the business is not near self-sustaining. Continued high cost base versus low, volatile revenue increases funding needs, complicates commercialization planning, and raises execution risk for long-term viability.