Strong Q1 Revenue Growth
Total product revenues of $93.4M in Q1 2026, up 38% year-over-year from $67.8M, driven primarily by Ibsrela demand.
Ibsrela Momentum and Guidance
Ibsrela Q1 revenue of $70.1M, up 58% YoY. Company reiterated 2026 Ibsrela guidance of $410M–$430M (50%–57% YoY growth) and long-term target of at least $1B in annual revenue by 2029 (~38% CAGR).
Exposa Underlying Growth and Long-Term Target Reiterated
Exposa reported $23.3M in Q1 revenues (as-reported roughly flat YoY), but underlying paid prescriptions grew ~19% YoY after adjusting for a $3.8M favorable return reserve in Q1 2025. Company reiterated long-term Exposa target of $750M and 2026 guidance of $110M–$120M.
Pipeline Progress — EXCEL Phase 3 and Pediatric Program
Initiated EXCEL Phase 3 trial of Ibsrela in CIC; all pre-identified sites initiated in under four months and enrollment is on track to complete by year-end with topline data expected in 2027. Ongoing pediatric studies may support label expansion and could yield an additional six months of exclusivity via SNDA; Orange Book-listed 2099 patent added for commercial formulations.
Next-generation Program Advancing
Next‑generation NHE3 inhibitor (531) progressing through IND‑enabling studies, positioning potential expansion into additional therapeutic areas.
Commercial Execution and Access Initiatives Driving Pull‑Through
Commercial initiatives (Ibsrela Pharmacy Network, increased field reimbursement managers) are improving fulfillment and refill behavior — specialty pharmacy channel is ~30% of mix and the network reportedly yields higher fill rates and on average an additional refill per year.
Improved Losses and Financial Position; Debt Refinancing
Net loss narrowed to $37.6M (−$0.15/share) vs $41.1M (−$0.17) prior year. Cash, cash equivalents and short‑term investments of $238.1M. Refinance with SLR extended loan maturity/interest-only period, lowered cost of capital and preserves $100M available drawdown.