Initiation of Pivotal Phase II Trial
Cellectis is preparing for the initiation of the pivotal Phase II trial for lasme-cel, UCART22, in relapsed or refractory acute lymphoblastic leukemia in the second half of 2025.
Financial Position
Cellectis' cash, cash equivalents, and fixed-term deposits as of June 30, 2025, amount to $230 million, sufficient to fund operations into H2 2027.
Progress in Clinical Trials
Recruitment to the dose escalation component of the Phase I BALLI-01 study evaluating UCART22 is complete. Cellectis is expanding trial sites in the US and Europe for Phase II.
Productive Regulatory Feedback
Cellectis received clear guidance from both the FDA and EMA on endpoints, study design, and statistical plans for lasme-cel, paving a clear path for the Phase II program.
Strategic Collaboration with AstraZeneca
Ongoing R&D activities under the partnership with AstraZeneca include three cell and gene therapy programs, with progress noted in allogeneic CAR-T for hematological malignancies and solid tumors.