Wells Fargo upgraded Septerna (SEPN) to Overweight from Equal Weight with a price target of $28, up from $18, after hosting investor meetings with management. The firm “gained confidence” on SEP-479’s safety profile and its “differentiation” relative to Septerna’s prior program. Wells sees SEP-479’s advancement into Phase 1 and SEP-631’s Phase 1 update in the first half of 2026 as key catalysts for the stock.
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