Telomir Pharmaceuticals announces new preclinical data on Telomir-1

Telomir Pharmaceuticals (TELO) announced new preclinical findings highlighting Telomir-1’s ability to reverse epigenetic gene silencing in aggressive human prostate cancer cells-achieving greater efficacy than Paclitaxel and Rapamycin in restoring the STAT1 tumor suppressor. STAT1, a master regulator of immune surveillance and programmed cell death, is frequently silenced in advanced cancers through promoter hypermethylation. In this state, cancer cells effectively disable one of the body’s key defense mechanisms-shutting down immune detection and blocking signals that would normally trigger their death. In this newly reported study, Telomir-1 administered orally over 21 days in a mouse model implanted with aggressive human prostate cancer cells fully reversed this hypermethylation in a dose-dependent fashion. In contrast, Paclitaxel showed no effect, and Rapamycin achieved only partial reduction of hypermethylation of STAT1. By restoring STAT1 activity, Telomir-1 may be reawakening the body’s built-in tumor suppressor system-allowing immune cells to once again recognize, target, and eliminate cancer. This mechanism offers a potential explanation for the tumor shrinkage observed by Telomir-1 and highlights a biological pathway not addressed by standard chemotherapy. In addition to STAT1, Telomir-1 also reduced hypermethylation of TMS1, a pro-apoptotic tumor suppressor commonly silenced in prostate cancer. While PTX and Rapamycin showed comparable or greater effects on TMS1 methylation, Telomir-1 is unique in its ability to modulate both STAT1 and TMS1-two genes that together regulate immune response and apoptosis.