Surface Oncology announces first patient dosed in Phase 1/2 study of SRF114

Surface Oncolog announced that the first patient has been dosed in its Phase 1/2 clinical study investigating SRF114, a potential best-in-class, fully human, afucosylated anti-CCR8 antibody, as a monotherapy in patients with advanced solid tumors. "Helping patients fight cancer by depleting intra-tumoral regulatory T cells (Tregs) has been a key goal of many immunotherapy strategies for quite some time. We believe by targeting CCR8, SRF114 is well suited to explore the promise of this approach," said Alison O’Neill, M.D., chief medical officer of Surface Oncology. "We selected our SRF114 antibody based on its highly specific binding properties to human CCR8 exclusively, which we believe positions it as a potential best-in-class anti-CCR8 antibody for the treatment of advanced solid tumors."