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Stoke Therapeutics initiated with a Buy at Jefferies

Jefferies initiated coverage of Stoke Therapeutics (STOK) with a Buy rating and $30 price target The firm likes the stock’s risk/reward into zorevunersen’s Phase III data for Dravet syndrome in the second half of 2027. The trial has a 40%-50% chance of producing differentiated efficacy, potentially opening up a $1B-$1.5B opportunity for Stoke, the analyst tells investors in a research note. Jefferies is looking forward to a potential “material update” from an FDA meeting in the second half of 2025.

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