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Spyre Therapeutics initiated with a Buy at Citi

Citi initiated coverage of Spyre Therapeutics (SYRE) with a Buy rating and $64 price target The firm says the company is developing “best-in-class” antibodies for autoimmune conditions. Citi sees meaningful upside potential in the company’s rheumatic disease program. It sees an inflection for the shares with data readouts in 2026 and 2027.

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