Spruce Biosciences downgraded to Neutral from Buy at H.C. Wainwright

H.C. Wainwright analyst Boobalan Pachaiyappan downgraded Spruce Biosciences to Neutral from Buy without a price target after the company’s CAHmelia-203 study of tildacerfont in adult classic congenital adrenal hyperplasia failed to meet the endpoint. The analyst believes the failure of the CAHmelia-203 trial introduces uncertainty around Spruce’s forward path and the timeline to potential completion of pivotal development and regulatory submission.

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