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Replimune downgraded to Neutral from Outperform at Wedbush

Wedbush downgraded Replimune (REPL) to Neutral from Outperform with a price target of $2, down from $19, after the FDA issued a second complete response letter for the company’s BLA for RP1 in combination with nivolumab in PD-1 refractory melanoma. Overall, Wedbush views the additional CRL as disappointing given what it viewed as convincing treatment effect in a patient population with significant unmet need.

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