Palisade Bio granted Canadian patent covering PALI-2108 composition

Palisade Bio (PALI) announced that the Canadian Intellectual Property Office has granted patent number 3,174,137 titled, “Gut Microbiota Bioactivated PDE4 Inhibitor Precursors.” The patent covers the composition of PALI-2108, the Company’s orally administered, first-in-class, ileocolonic-targeted PDE4 B/D inhibitor in development for the treatment of FSCD and UC. The patent provides composition-of-matter protection for PALI-2108 through May 28, 2041. PALI-2108’s unique design incorporates a galactose-derived sugar moiety that allows for minimal absorption until converted by the colonic bacterium enzyme beta-glucuronidase. This mechanism is intended to ensure localized bioactivation, leading to colon-specific distribution with reduced systemic exposure, as demonstrated in a tissue distribution study. Palisade Bio continues to advance the development of PALI-2108 in its Phase 1b FSCD study with patient dosing expected to commence in H2 2025 and topline data expected in Q1 2026. Data from the FSCD Phase 1b, together with results from Palisade’s completed Phase 1a/1b trials in UC, will support the Company’s planned Phase 2 IND submission to the U.S. Food and Drug Administration in the first half of 2026.