PacBio, UC Davis Researchers introduce CiFi

PacBio (PACB) announced CiFi, a new community-developed method that enables chromosome-scale, haplotype-resolved genome assemblies from a single sequencing run. By integrating chromatin conformation capture with PacBio HiFi long-read sequencing, CiFi delivers multi-contact reads and longer fragments that increase the information content of proximity ligation experiments in a single Revio sequencing run. “CiFi expands our multiomics capabilities, increasing what we can do on HiFi sequencing systems without new hardware and unlocking new customer use cases,” said David Miller, Vice President of Global Marketing at PacBio. “The work from the Megan Dennis Lab at UC Davis shows what becomes possible when innovative chromatin capture methods are paired with the accuracy of HiFi sequencing.”