Metagenomi announces publication on MG119-28

Metagenomi (MGX) Therapeutics announced a publication in Nature Structural & Molecular Biology highlighting the discovery and detailed characterization of MG119-28, a compact CRISPR nuclease with superior editing efficiency relative to previously identified compact nucleases. The publication, titled “Comparative characterization of Cas12f orthologs reveals mechanistic features underlying enhanced genome editing efficiency” highlights the potential of MG119-28 to overcome low editing efficiency in mammalian systems of previously identified compact nucleases from the Cas12f class. “The publication demonstrates that the enhanced editing performance is due to superior structural stability of the protein and inherently more stable guide RNA which enables faster DNA cleavage activity. The structural and mechanistic insights enabled engineering of MG119-28 to further improve activity across multiple target genes,” the company said.